皮肤MALT淋巴瘤缺乏t(11;18)(q21;q21)/API2-MALT1和t(14;18)(q34;q21)/IGH-MALT1  

ABSENCE OF t(11;18)(q21;q21)/API2-MALT1 AND t(14;18)(q34;q21)/IGH-MALT1 IN PRIMARY CUTANEOUS MALT LYMPHOMA

作　　者：周英琼[1] 宫丽平[2] 侯巧燕[1] 肖胜军[1] 郭芳[1] 叶洪涛[1] 

机构地区：[1]桂林医学院附属医院病理科,桂林541001 [2]首都医科大学病理系

出　　处：《广西医科大学学报》2009年第2期197-199,共3页Journal of Guangxi Medical University

基　　金：国家自然科学基金(30760081);广西自然科学基金(桂科自0499015和桂科自0848012);广西病理学人才小高地创新团队

摘　　要：目的:探讨黏膜相关淋巴组织(MALT)淋巴瘤中常见的两个染色体易位t(11;18)(q21;q21)/API2-MALT1和t(14;18)(q34;q21)/IGH-MALT1在皮肤MALT淋巴瘤中的发生率。方法:采用MALT1及IGH双色分离探针,对19例皮肤MALT淋巴瘤标本进行间期荧光原位杂交(FISH)。结果:19例皮肤MALT淋巴瘤中均未检测到涉及MALT1基因的染色体易位,但发现2例(2/19,11%)存在MALT1基因的3个拷贝现象。结论:涉及MALT1基因的染色体易位,即t(11;18)(q21;q21)/API2-MALT1和t(14;18)(q34;q21)/IGH-MALT1在皮肤MALT淋巴瘤罕见或不见。Objective.t（ll;18）（q21;q21）/API2-MALT1 and t（14;18）（q34;q21）/IGH-MALT1 have been reported in cutaneous MALT lymphoma. However, the incidence of t（11;18）（q21;q21）/API2-MALT1 and t（14;18）（q34;q21）/IGH-MALT1 in this kind of cutaneous lymphoma remains unclear. Methods. 19 cases of cutaneous MALT lymphoma were screened by interphase FISH analysis using MALT1 and IGH break apart probes. Results： The translocations involving MALT1 were not detected in all of the 19 cutaneous MALT lymphoma, but 3 copies of MALT1 gene were detected in two of the 19 cases （11%） . Conclusion：This study demonstrated that translocations involving MALT1 gene, including API2-MALT1 and IGH-MALT1 are absence or at least uncommon in cutaneous MALT lymphoma.

关 键 词：皮肤 MALT淋巴瘤 染色体易位 FISH 

分 类 号：R733.4[医药卫生—肿瘤]