Design,synthesis and characterization of novel biodegradable macrodiols based on poly(DL-lactic acid) and poly(p-dioxanone)  

作　　者：Chan Yu Zhang Yan Feng Luo Su Jun Wang Zhao Liu Yuan Liang Wang Zhi Qing Liang 

机构地区：[1]College of Bioengineering, Chongqing University, Research Center of Bioinspired Material Science and Engineering (BIMSEC), Chongqing 400030, China [2]Department of Gynecology and Obstetrics, Southwest Hospital, Third Military Medical University, Chongqing 400038, China

出　　处：《Chinese Chemical Letters》2009年第6期743-746,共4页中国化学快报（英文版）

基　　金：supported by the National Key Technologies R&D Program of China(No.2006BA103B04);the Natural Key Scientific and Technological Project of Chongqing(No.CSTC 2008AB0027)

摘　　要：Integrating poly（lactic acid） （PLA）, glycolic acid （GA） and ethylene glycol （EG） will hopefully result in a novel copolymer that combines such advantages as fastened and controllable release rate and improved flexibility together with good biocompatibility. In this study, p-dioxanone （PDO） was employed to copolymerize with DL-lactide （LA） via ring-opening melt polymerization using Sn（Oct）2 as an initiator and ethylene glycol as a co-initiator. The obtained degradable macrodiols （HO-P（LA-co-PDO）-OH） were just such a copolymer consisting of PLA, GA and EG. 1HNMR was employed to characterize the copolymers, and the effect of PDO/LA molar ratios in the feedstock on the molecular weights of HO-P（LA-co-PDO）-OH was investigated by means of endhydroxyl analysis, 1H NMR or GPC-MALLs. The results confirmed the successful synthesis of HO-P（LA-co-PDO）-OH and revealed that one end-hydroxyl of the micarodiols was donated by LA or PDO and the other one by the co-initiator EG. In addition, the molecular weights of HO-P（LA-co-PDO）-OH increased with decreasing PDO/LA ratios.Integrating poly（lactic acid） （PLA）, glycolic acid （GA） and ethylene glycol （EG） will hopefully result in a novel copolymer that combines such advantages as fastened and controllable release rate and improved flexibility together with good biocompatibility. In this study, p-dioxanone （PDO） was employed to copolymerize with DL-lactide （LA） via ring-opening melt polymerization using Sn（Oct）2 as an initiator and ethylene glycol as a co-initiator. The obtained degradable macrodiols （HO-P（LA-co-PDO）-OH） were just such a copolymer consisting of PLA, GA and EG. 1HNMR was employed to characterize the copolymers, and the effect of PDO/LA molar ratios in the feedstock on the molecular weights of HO-P（LA-co-PDO）-OH was investigated by means of endhydroxyl analysis, 1H NMR or GPC-MALLs. The results confirmed the successful synthesis of HO-P（LA-co-PDO）-OH and revealed that one end-hydroxyl of the micarodiols was donated by LA or PDO and the other one by the co-initiator EG. In addition, the molecular weights of HO-P（LA-co-PDO）-OH increased with decreasing PDO/LA ratios.

关 键 词：Macrodiol Poly（lactici acid） P-DIOXANONE Ethylene glycol Drug delivery carder Bone morphogenetic protein 

分 类 号：TQ921.3[轻工技术与工程—发酵工程] X172[环境科学与工程—环境科学]