中国人群膳食黄曲霉毒素致肝癌的暴露评估  

Exposure assessment of liver cancer attributed to dietary aflatoxins exposure in Chinese residents

作　　者：王君[1] 刘秀梅[1] 张志强[2] 

机构地区：[1]中国疾病预防控制中心营养与食品安全所,北京100021 [2]卫生部卫生监督中心

出　　处：《中华预防医学杂志》2009年第6期478-481,共4页Chinese Journal of Preventive Medicine

基　　金：基金项目：国家科技支撑项目（2006BAK02A20）;国家自然科学基金（30070660）

摘　　要：目的评估我国人群膳食黄曲霉毒素暴露引发肝癌的危险。方法用数学模型和暴露限值（MOE）两种方法对我国人群膳食黄曲霉毒素进行了暴露评估。数学模型中使用的资料来源于联合国粮农组织和世界卫生组织食品添加剂联合专家委员会（JECFA）和2004年我国居民血样乙型肝炎病毒（HBV）标志物的调查。MOE模型中使用的资料来源于动物实验研究资料、第四次中国居民营养与健康状况调查以及国家食品污染物监测网。结果数学模型方法表明，对我国膳食黄曲霉毒素暴露处于平均水平（665．43ng／标准人日）的人群，由黄曲霉毒素暴露导致的肝癌发病率为每年0．4033／10万；对于膳食黄曲霉毒素暴露处于高水平（第97．5百分位，24787．20ng／标准人日）的人群，由黄曲霉毒素暴露导致的肝癌发病率为每年15．0215／10万。MOE方法表明，在全国、城市和农村处于平均膳食黄曲霉毒素暴露水平（分别为0．01109、0．00813、0．01249μg·kg^-1·d^-1）下的人群中，黄曲霉毒素导致肝癌的MOE值分别为9017．1、12304．7和8006．4；对处于高膳食黄曲霉毒素暴露（第97．5百分位，分别为0．41310、0．28930、0．48950μg·kg^-1·d^-1）的全国、城市和农村人群而言，由黄曲霉毒素暴露导致肝癌的MOE值分别为242．1、345．7、204．3。结论对膳食黄曲霉毒素处于平均暴露水平的人群，膳食黄曲霉毒素暴露导致肝癌的危险属于中度，对于高暴露水平的人群，膳食黄曲霉毒素暴露导致肝癌的危险属于高度。Objective To evaluate the risk of liver cancer attributed to dietary aflatoxins exposure in Chinese residents. Methods Mathematics model and ＂Margin of Exposure （ MOE ） ＂ methods were employed in this study. The data used in mathematics model came from Joint FAO/WHO Expert Committee on Food Additives （JECFA） and the detection results of hepatitis B virus （ HBV ） indicator in Chinese residents＇ blood sample in 2004. The data used in MOE model came from animal experiments, the fourth nutrition and health investigation among Chinese residents, and national inspection network for food contaminations. Results Mathematics model indicated that for those people who were exposed to aflatoxins at average level （665.43 ng/d）, the liver cancer incidence rate resulting from aflatoxins exposure was 0. 4033 per 100 thousand person years. For those people who were exposed to aflatoxins at a high level （ 97.5 percentile ,24 787.20 ng/d） the liver cancer incidence rate attributed to aflatoxins exposure was 15. 0215 per 100 thousand person years. Results from the MOE method showed that for the people in whole country,urban and rural areas who were exposed to aflatoxins at average level （0. 011 09,0. 008 13 and 0. 012 49 μg·kg^-1·d^-1 respectively）, the MOE values for aflatoxins to cause liver cancer were 9017.1,12 304. 7 and 8006.4 respectively. For those people who were exposed to aflatoxins at a high level （ 97.5 percentile, 0. 413 10,0. 289 30 and 0. 489 50 μg· kg^-1· d^-1 respectively）, the MOE values for aflatoxins to cause liver cancer were 242. 1,345.7 and 204. 3 for whole country, urban and rural areas, respectively. Conclusion For the people whose dietary aflatoxins exposure at average level, the risk of liver cancer attributed to aflatoxins is middle. For the people whose dietary aflatoxins exposure at high level, this kind of risk should be high.

关 键 词：膳食 黄曲霉毒素类 肝肿瘤 危险.陛评估 暴露限值 

分 类 号：R686[医药卫生—骨科学]