苯菌酮的合成  

Synthesis of Metrafenone

作　　者：陈一芬[1] 万欢[1] 臧佳良[1] 冀亚飞[1] 

机构地区：[1]华东理工大学药学院,上海200237

出　　处：《合成化学》2009年第3期390-391,396,共3页Chinese Journal of Synthetic Chemistry

摘　　要：2-甲氧基-6-甲基苯甲酸经溴化制得5-溴-2-甲氧基-6-甲基苯甲酸(3);3与氯化亚砜进行酰氯化反应,再与3,4,5-三甲氧基甲苯进行傅-克酰基化反应合成了苯菌酮,总收率74.2%,其结构经1HNMR和MS确证。Metrafenone in an overall yield of 74.2% was synthesized from 5-bromo-2-methoxy-6- methylbenzoic acid（3） by an acylchlorination with thionyl chloride, then by a Friedel-Crafts aeylation with 3,4,5-trimethoxytoluene. 3 was prepared by the bromination of 2-methoxy-6-methylbenzoic acid. The structure of metrafenone was confirmed by ^1H NMR and MS.

关 键 词：苯菌酮 溴化 酰氯化 合成 

分 类 号：O625.4[理学—有机化学] O625.2[理学—化学]