新型氟喹诺酮化合物的设计及合成  

Design and synthesis of new type of fluoroquinolones

作　　者：潘佳[1] 魏臣録 翁玲玲[1] 

机构地区：[1]四川大学华西药学院,四川成都610041

出　　处：《华西药学杂志》2009年第3期215-217,共3页West China Journal of Pharmaceutical Sciences

摘　　要：目的设计并合成新的氟喹诺酮化合物。方法以左氧氟沙星中间体(-)-9,10-二氟-2,3-二氢-3-甲基-7-氧代-7H-吡啶并[1,2,3-de]-[1,4]苯并噁嗪-6-羧酸乙酯为原料,经叠氮化、氢化、酰化、水解来合成目标物。结果与结论合成的8个新型氟喹诺酮类化合物均经核磁共振谱确证结构。OBJECTIVE To design and synthesize new fluoroquinolone derivatives. METHODS The title compounds were synthesized primarily from （S） - ethyl 9,10 - difluoro - 3 - methyl - 7 - oxo - 3,7 - dihydro - 2H - [ 1,4 ] oxazino [ 2,3,4 - ij ] quinoline - 6 - carboxylate through diazotization, hydrogenation, acylation and hydrolyzation. RESULTS and CONCLUSION 8 new compounds were synthesized. The structures of the title compounds were confirmed by ^1HNMR and ^13CNMR.

关 键 词：喹诺酮 合成 左氧氟沙星 

分 类 号：R914[医药卫生—药物化学]