不同酒类致酒精性肝损伤的病理学比较  

Pathological changes of alcoholic hepatic injury caused by different alcohols in rats

作　　者：董瑞玲[1] 张京玲[2] 张中礼[2] 宋振国[2] 白雪[2] 王晨光[2] 黎俊[2] 

机构地区：[1]南开大学医院,天津市300071 [2]南开大学医学院

出　　处：《河北医药》2009年第10期1172-1174,共3页Hebei Medical Journal

摘　　要：目的观察不同酒类对肝脏细胞的损伤作用。方法将Waister大鼠100只随机分为3组:对照组20只,用等体积的等渗氯化钠溶液代替酒精灌胃;红酒组与白酒组各40只,分别给大鼠灌入大剂量的红葡萄酒、烈性白酒,3个月后处死动物,摘取肝脏,制备成病理切片,在光镜和电镜下观察肝脏的形态学变化。结果烈性白酒可严重损伤肝细胞,导致酒精性肝炎与脂肪肝,与对照组及同时段红酒组比较,差异均有统计学意义(P<0.05或0.01),红葡萄酒对肝脏损伤轻微,为可逆性病变。结论长期或大量饮用烈性白酒可造成不可逆的肝脏损伤,导致酒精性肝炎与严重的脂肪肝。大量红葡萄酒的这种损伤作用则比较轻微。Objective To observe the effect of various alcohols on liver. Methods 100 Wistar rats were randomly divided into 3 groups, 40 rats in red wine group were given high-dose red wine and 40 rats in violent alcohol group were given high-dose violent alcohol, and 20 rats in control group were given NS at the same dose as that in two experimental groups by gavage,with a course of 3 months for the three groups. All the rats were killed after three months and their livers were taken to be examined by pathology. The morphological changes of liver cells were observed with light and electron microscope. Results Liver cells were severe damaged by violent alcohol, which resulted in alcoholic hepatitis and fat liver. There were significant differences in various parameters between violent alcohol group and red wine group as well as control group （ P 〈 0.05 or 〈 0.01 ）. Conclusion Drinking high-dose violent alcohol at long term can cause inconvertible liver damage, which can result in alcoholic hepatitis and fat liver. However red wine causes light damage of liver cells, furthermore, the changes are reversible.

关 键 词：大鼠 烈性白酒 红葡萄酒 脂肪肝 病理学观察 

分 类 号：R575[医药卫生—消化系统]