Curcumin inhibits amygdaloid kindled seizures in rats  被引量:2

Curcumin inhibits amygdaloid kindled seizures in rats

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作  者:DU Peng LI Xin LIN Hao-jie PENG Wei-feng LIU Jian-ying MA Yu FAN Wei WANG Xin 

机构地区:[1]Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200032, China [2]Institute of Brain Science, Fudan University, Shanghai 200032, China

出  处:《Chinese Medical Journal》2009年第12期1435-1438,共4页中华医学杂志(英文版)

摘  要:Background Curcumin can reduce the severity of seizures induced by kainate acid (KA), but the role of curcumin in amygdaloid kindled models is still unknown. This study aimed to explore the effect of curcumin on the development of kindling in amygdaloid kindled rats. Methods With an amygdaloid kindled Sprague-Dawley (SD) rat model and an electrophysiological method, different doses of curcumin (10 mg·kg^-1·d^-1 and 30 mg·kg^-1·d^-1 as low dose groups, 100 mg·kg^-1·d^-1 and 300 mg·kg^-1·d^-1 as high dose groups) were administrated intraperitoneally during the whole kindling days, by comparison with the course of kindling, afterdischarge (AD) thresholds and the number of ADs to reach the stages of class I to V seizures in the rats between control and experimental groups. One-way or two-way ANOVA and Fisher's least significant difference post hoc test were used for statistical analyses. Results Curcumin (both 100 mg·kg^-1·d^-1 and 300 mg·kg^-1·d^-1 ) significantly inhibited the behavioral seizure development in the (19.80±2.25) and (21.70±2.21) stimulations respectively required to reach the kindled state. Rats treated with 100mg·kg^-1·d^-1 curcumin 30 minutes before kindling stimulation showed an obvious increase in the stimulation current intensity required to evoke AD from (703.3±85.9) μA to (960.0±116.5) μA during the progression to class V seizures. Rats treated with 300 mg·kg^-1·d^-1 curcumin showed a significant increase in the stimulation current intensity required to evoke AD from (735.0±65.2) μA to (867.0±93.4) μA during the progression to class V seizures. Rats treated with 300mg·kg^-1·d^-1 curcumin required much more evoked ADs to reach the stage of class both IV (as (199.83±12.47) seconds) and V seizures (as (210.66±10.68) seconds). Rats treated with 100 mg·kg^-1·d^-1 curcumin required much more evoked ADs to reach the stage of class V seizures (as (219.56±18.24) seconds). Conclusion Our study suggeBackground Curcumin can reduce the severity of seizures induced by kainate acid (KA), but the role of curcumin in amygdaloid kindled models is still unknown. This study aimed to explore the effect of curcumin on the development of kindling in amygdaloid kindled rats. Methods With an amygdaloid kindled Sprague-Dawley (SD) rat model and an electrophysiological method, different doses of curcumin (10 mg·kg^-1·d^-1 and 30 mg·kg^-1·d^-1 as low dose groups, 100 mg·kg^-1·d^-1 and 300 mg·kg^-1·d^-1 as high dose groups) were administrated intraperitoneally during the whole kindling days, by comparison with the course of kindling, afterdischarge (AD) thresholds and the number of ADs to reach the stages of class I to V seizures in the rats between control and experimental groups. One-way or two-way ANOVA and Fisher's least significant difference post hoc test were used for statistical analyses. Results Curcumin (both 100 mg·kg^-1·d^-1 and 300 mg·kg^-1·d^-1 ) significantly inhibited the behavioral seizure development in the (19.80±2.25) and (21.70±2.21) stimulations respectively required to reach the kindled state. Rats treated with 100mg·kg^-1·d^-1 curcumin 30 minutes before kindling stimulation showed an obvious increase in the stimulation current intensity required to evoke AD from (703.3±85.9) μA to (960.0±116.5) μA during the progression to class V seizures. Rats treated with 300 mg·kg^-1·d^-1 curcumin showed a significant increase in the stimulation current intensity required to evoke AD from (735.0±65.2) μA to (867.0±93.4) μA during the progression to class V seizures. Rats treated with 300mg·kg^-1·d^-1 curcumin required much more evoked ADs to reach the stage of class both IV (as (199.83±12.47) seconds) and V seizures (as (210.66±10.68) seconds). Rats treated with 100 mg·kg^-1·d^-1 curcumin required much more evoked ADs to reach the stage of class V seizures (as (219.56±18.24) seconds). Conclusion Our study sugge

关 键 词:CURCUMIN AMYGDALA kindling  neurologic EPILEPTOGENESIS 

分 类 号:R686[医药卫生—骨科学]

 

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