姜黄素前体药物FM0806的初步稳定性及其水解动力学  

Study on the stability of curcumine prodrug FM0806 and its hydrolysis kinetics

作　　者：林燕芳[1] 许建华[1] 黄秀旺[1] 

机构地区：[1]福建医科大学药学院福建医科大学临床药理所,福建福州350004

出　　处：《世界肿瘤杂志》2009年第2期107-109,共3页Tumour Journal of the World

基　　金：国家自然科学基金资助项目（30873101）

摘　　要：目的研究姜黄素前体药物的稳定性及其水解动力学。方法利用HPLC法测定FM0806在不同pH值的缓冲溶液、血浆及肝匀浆中药物水解动力学。结果姜黄素前体药物FM0806在pH为2～10时水解速率常数不受pH影响，而在血浆及肝均浆中FM0806可迅速水解。结论FM0806是一个具有良好前景的姜黄素前体药物。Objective To investigate the stability and the kinetic of curcumine prodrug FM0806. Methods Prodrug hydrolysis was studied in aqueous buffer solutions with pH 2-10 as well as 80% rat plasma solution and homogenized liver by the reversed-phase high performance liquid chromatography （RP-HPLC） Method. Results The velocity of hydrolysis of FM0806 kept the same level under pH 2-10,and it could be hydrolyzed fast by enzymes in blood plasma, homogenized liver. Conclusions FM0806 was a promising prodrug ofcurcumine.

关 键 词：姜黄素 前体药物 水解速率常数 肝匀浆 

分 类 号：R73-34[医药卫生—肿瘤]