L-苯丙氨酸与精左氨基物偶联反应的研究  

Investigation on the Coupling Reaction of L-Phenylalanine with Chloramphenicol Base

作　　者：许荩[1] 范莉[1] 付成松[1] 宋小礼[1] 李金鹏[1] 杨大成[1] 

机构地区：[1]西南大学化学化工学院,重庆400715

出　　处：《西南大学学报（自然科学版）》2009年第6期184-188,共5页Journal of Southwest University(Natural Science Edition)

基　　金：重庆市自然科学基金资助项目(2005BB5095);西南师范大学博士科研基金资助项目(SWNU.B2005010);西南师范大学高新技术培育基金资助项目(XSGX05)

摘　　要：采用叔丁氧羰基(Boc)、苄氧羰基(Z)和芴甲氧羰基(Fmoc)这3种保护基保护苯丙氨酸的氨基,顺利得到3个保护的苯丙氨酸(Ⅲa-c);保护的苯丙氨酸与精左氨基物(Ⅱ)进行偶联,较高收率地合成了3个未见文献报道的目标分子(Ⅳa-c),产物的结构通过IR,1H NMR,13C NMR测试得到了验证.对氨基酸的保护及偶联反应的条件进行了优化.With butyloxycarbonyl （Boc）, benzyloxycarbonyl （Z） and fluorenylmethyloxycarbonyl （Fmoc） as protecting groups, three amino group-protected L-phenylalanines were successfully obtained. Aided by different coupling reagents, three new conjugated products of the amino group-protected L-phenylalanines with chloramphenicol base were synthesized with a yield of 70%- 78%. The chemical structures of the new compounds were confirmed by IR, 1H NMR, and 13C NMR. The conditions for the reactions mentioned above were optimized.

关 键 词：L-苯丙氨酸 精左氨基物 氨基保护 偶联反应 

分 类 号：R914.4[医药卫生—药物化学]