抗癌钌配合物NAMI-A和ICR的合成、水解及其与DNA的相互作用  

Synthesis,hydrolysis and interaction with DNA of anticancer ruthenium complexes NAMI-A and ICR

作　　者：王飞利[1] 柴晓华[1] 聂万利[2] 陈国亮[1] 李恒欣[2] 耿超[1] 

机构地区：[1]西北大学化工学院,陕西西安710069 [2]西北大学化学与材料科学学院,陕西西安710069

出　　处：《化学试剂》2009年第5期324-326,392,共4页Chemical Reagents

基　　金：陕西省自然科学基金资助项目(2006B02)

摘　　要：以RuCl3、DMSO、Im为原料合成了抗癌钌配合物NAMI-A和ICR,进行必要的表征。利用紫外-可见吸收光谱研究了它们在水、DMSO的水溶液、磷酸缓冲溶液(PBS)中的水解情况及其在磷酸缓冲溶液中与DNA相互作用。结果表明,钌配合物在水、DMSO的水溶液和磷酸缓冲溶液(PBS)中的水解性质有较大的差距,与DNA可能以配体嵌插或沟槽作用方式结合。Ruthenium-anticaneer complexes NAMI-A and ICR were synthesized using ruthenium triehloride, dimethylsulfoxide and imidazole as the starting materials and were characterized by EA, IR and UV. Their hydrolysis in water, aqueous solution of DMSO and phosphate buffer solution （PBS）, and their interaction with DNA in PBS were studied by the UV spectrometry.

关 键 词：钌配合物 水解 抗癌活性 DNA 

分 类 号：O614.82[理学—无机化学]