食管癌变过程中cyclin D1和Rb的表达及其意义的前瞻性研究  

Prospective study on expressions of cyclin D1 and Rb and significance in carcinogenesis of the esophagus

作　　者：刘海明 杨观瑞[2] 李小环[3] 

机构地区：[1]河南省卫生学校附属医院,河南安阳455000 [2]河南省医学科学研究所,河南郑州450052 [3]新乡市中心医院,河南新乡453000

出　　处：《现代肿瘤医学》2009年第7期1262-1264,共3页Journal of Modern Oncology

摘　　要：目的:探讨cyclinD1和Rb基因在食管癌变过程中的表达及其意义。方法:应用免疫组织化学S-P法检测cyclinD1和Rb基因在17例癌变组和40例非癌变组中的表达。结果:CyclinD1在癌变组中的表达增高(P<0.05),cyclinD1与Rb在早期癌中的表达存在正相关(P<0.05)。结论:CyclinD1基因的过表达和食管癌的发生有关,cyclinD1和Rb基因表达的变化可能是食管癌发生中的早期事件。Objective：To study the expressions of cyclin D1 and Rb gene in esophageal carcinogenesis and significance. Methods： Immunohistochemical S - P method was used to detect the expressions of cyclin D1 and Rb gene in 17 cases in cancer group ,40 cases in non - cancer group. Results：The expression of cyclin D1 was higher in cancer group （P 〈0. 5）. There was positive correlation between expression of cyclin D1 and Rb in early carcinoma （ P 〈 0.05 ）. Conclusion：The expression of cyclin D1 was related to esophageal carcinogenesis, and it maybe early event in esophageal carcinogenesis.

关 键 词：CYCLIN D1 RB 食管癌变过程 免疫组织化学 

分 类 号：R735.1[医药卫生—肿瘤]