急性早幼粒白血病复合型染色体易位及其临床预后相关性的研究  

STUDIES ON COMPLEX CHROMOSOMAL TRANSLOCATIONS AND THEIR RELEVANCE TO CLINICAL PROGNOSIS IN ACUTE PROMYELOCYTIC LEUKEMIA

作　　者：苏欣莹[1] 何凯莉[1] 牛超[1] 顾柏炜[1] 曹琪[1] 陈竺[1] 陈赛娟[1] 

机构地区：[1]上海市血液学研究所,上海第二医科大学附属瑞金医院

出　　处：《中华医学遗传学杂志》1998年第4期198-201,共4页Chinese Journal of Medical Genetics

基　　金：国家自然科学基金;上海血液学研究所胡应洲基金

摘　　要：目的研究急性早幼粒白血病（ａｃｕｔｅｐｒｏｍｙｅｌｏｃｙｔｉｃｌｅｕｋｅｍｉａ，ＡＰＬ，Ｍ３）中复合型染色体易位与临床治疗、预后的关系。方法应用常规核型分析、荧光原位杂交和逆转录酶／聚合酶链反应，检测了３例ＡＰＬ，Ｍ３。结果发现３例均有早幼粒白血病基因－维甲酸受体α基因（ｐｒｏｍｙｅｌｏｃｙｔｉｃｌｅｕｋｅｍｉａｇｅｎｅ－ｒｅｔｉｎｏｉｃａｃｉｄｒｅｃｅｐｔｏｒαｇｅｎｅ，ＰＭＬ－ＲＡＲα）融合基因转录本；核型呈复合型易位，除有１５和１７号染色体易位外还累及了５、１１、１６、２２号多条染色体，并与临床预后有一定相关性。结论对ＡＰＬ复合型易位的检测和深入研究。Objective To study the relationship between the complex chromosome translocation in acute promyelocytic leukemia(APL,M3) and clinical therapy and prognosis.Methods Chromosome translocations and PMLRAR fusion transcript in three APL patients were studied by using karyotypic analysis, fluorescence in situ hybridization and reverse transcriptase/polymerase chain reaction.Results The findings revealed that all these cases had PML/RARα gene rearrangement. Apart from the chromosomes 15 and 17 involved in the translocation, other multiple chromosomes including 5, 11, 16, 22 were also implicated in complex translocations, which to some extent seemed to be related with clinical prognosis.Conclusion This study provides additional information for monitoring clinical therapy and prognostic evaluation.

关 键 词：白血病 APL 染色体易位 预后 

分 类 号：R733.71[医药卫生—肿瘤]