同型半胱氨酸与中青年脑梗死的关系  

The relationship between homocysteine and the ischemic stroke in young and middle-aged adults

作　　者：李海平[1] 李威[1] 王红艳[1] 

机构地区：[1]北华大学附属医院神经内科,吉林吉林132011

出　　处：《中风与神经疾病杂志》2009年第3期313-315,共3页Journal of Apoplexy and Nervous Diseases

摘　　要：目的探讨血浆同型半胱氨酸(Hcy)水平与中青年脑梗死的关系,并评价Hcy在中青年脑梗死的发生发展中的作用和意义。方法应用酶联免疫吸附试验(ELISA)测量52例中青年脑梗死患者血浆Hcy水平。结果中青年脑梗死患者血浆Hcy水平高于对照组。血浆Hcy水平越高急性期脑梗死的梗死灶越大,两者呈直线相关关系,正相关。结论高同型半胱氨酸(HH)是动脉粥样硬化的危险因素,HH在中青年中发病率较高。血浆Hcy浓度越高的急性期脑梗死者梗死灶体积越大。血浆Hcy浓度能反应梗死灶的大小及病情的程度,对有脑血管病倾向的中青年血浆Hcy可作为常规检查或作为病情监测和预后估计指标,以便采取干预措施,对预防和减少脑血管病的发病有十分重要的意义。Objective To study the relationship between plasma homocysteine （Hcy） level and ischemic stroke in young and middle-aged adults and to evaluate its effects and significance concerning the occurrence and development of ischemic stroke among young and middle-aged adults. Methods The plasma Hcy level of 52 young and middle-aged adults patients with ischemic stroke were measured by means of enzyme linked immunosobent assay （ELISA）. Results The plasma Hcy level in ischemic stroke were higher than those in control group. The higher the plasma Hcy level, the bigger the infarcted focus in acute ischemic stroke group of young and middle-aged adults. The plasma Hcy level and the infarcted focus were positively linearly correlated. Conclusions HH is a risk factor of atherosclerotic disease. HH is common in ischemic stroke patients, and its occurrence in the young and middle-aged is higher. The higher the Hcy level, the larger the infarcted focus. Therefore the Hcy can reflect the size of the infarcted focus and the degree of disease. The Hcy level can serve as a kind of regular examination or as an index of disease monitoring and prognosis evaluating so that some intervention can be taken, all of which are of great importance to prevent ischemic stroke and reduce its morbility.

关 键 词：同型半胱氨酸 脑梗死 中青年 酶联免疫吸附试验 

分 类 号：R743.3[医药卫生—神经病学与精神病学]