丙戊酸钠单药治疗首诊癫痫患儿的P300短期变化分析  

Analysis of the short change of event related potential p300 before and after valproate treatment in children with epilepsy

作　　者：索军芳[1] 王浙东[1] 吉永春[1] 沈廉娟[1] 

机构地区：[1]苏州大学附属儿童医院,江苏苏州215003

出　　处：《医学研究与教育》2009年第3期29-30,35,共3页Medical Research and Education

摘　　要：目的采用事件相关电位P300研究癫痫患儿治疗前后的的认知功能短期变化,探讨癫痫儿童认知功能的影响因素。方法对30例首诊的丙戊酸钠单药治疗的癫痫儿童和30例正常对照儿童分别进行事件相关电位P300测定。并对治疗组儿童服药3月后进行P300复查。结果事件相关电位P300的潜伏期:服药前组儿童(394.33±35.19)ms明显高于正常对照组(347.90±15.01)ms(P<0.01),差异有统计学意义。服药后组(367.60±16.89)ms仍高于对照组(P<0.01),但较治疗前明显缩短(P<0.01),差异有统计学意义。结论癫痫儿童存在认知功能受损,早期用药可减轻认知功能受损。Objective To observe the short change of event-related potential P300 at the early period of therapy in children with epilepsy, and explore the influence factor of their cognitive functions. Methods Examine P300 of 30 cases of children with epileptic before valproate treatment and 30 cases of healthy children,and check the P300 of children with epileptic again three months after treatment. Results The latency of P300 in children with epilepsy before treatment（394.33±35.19）ms showed significantly longer than that in controls（347.90±15.01 ） ms （P〈0.01）, in children epilepsy after treatment（367.60±16.89）ms showed significantly longer than the controls （P〈0.01）, but is shorter than the children before treatment （P〈0.01）. Conclusion The cognitive functions of children with epilepsy are damaged, early and rational administration of drug may relieve the damage.

关 键 词：癫痫 P300 EEG 认知功能 丙戊酸钠 

分 类 号：R749.17[医药卫生—神经病学与精神病学]