轮梗霉融合株菌粉营养价值和调节血脂的研究  

Nutritional Value of Mycelia of Diasporangium sp.Recombinant Strain and Their Regulation Effect on Blood Lipids in Mice

作　　者：赵沫[1] 戴传超[1] 夏顺翔[1] 管娴月[1] 朱明[2] 阎斌伦[2] 

机构地区：[1]南京师范大学生命科学学院,江苏省生物多样性与生物技术重点实验室,江苏南京210046 [2]淮海工学院江苏省海洋生物技术重点建设实验室,江苏连云港222005

出　　处：《食品科学》2009年第15期223-226,共4页Food Science

基　　金："十一五"国家科技支撑计划项目(2006BAD27B09);江苏省海洋生物技术重点建设实验室开放项目(2007HS012)

摘　　要：分析了经与黑曲霉基因组全序列杂交改造的轮梗霉融合株D-A1菌粉的一般营养成分及其对高脂小鼠血脂的调节作用和对动脉粥样硬化的预防。结果表明:菌粉含有15.21%的蛋白质和30.34%的粗脂肪,其中含有16.75%的花生四烯酸;以1.2g/kg菌粉饲喂小鼠35d,可有效预防血清总胆固醇(TC)、甘油三酯(TG)的升高,与高脂模型组相比,低密度脂蛋白-胆固醇(LDL-C)水平降低了70.94%,而高密度脂蛋白-胆固醇(HDL-C)水平提高了42.58%。轮梗霉融合株菌粉营养价值高,能有效的预防高脂血症,对小鼠脂代谢紊乱具有显著的调节作用。The dried mycelia of Diasporangium sp. recombinant strain D-A 1 which was a hybrid of Aspergillus niger and Diasporangium sp. obtained by genome shuffling was analyzed for their general nutritional ingredient and their regulation effect on blood lipids and prevention effect on atherosclerosis in mice were studied. The dried mycelia of the recombinant strain D-A1 contained 15.21% protein and 30.34% lipid of which arachidonic acid accounted for 16.75%. Obvious preventions in ascension of total cholesterol （TC） and triglyceride （TG） were found in high-fat model mice fed 1.2 g/kg of the dried mycelia of the recombinant strain D-A1 for 35 days. The low-density lipoprotein cholesterol （LDL-C） level of mycelia powder-fed group was reduced by 70.94% when compared with that of the high-fat diet model group, while the high-density lipoprotein cholesterol （HDL-C） level was found to be enhanced by 42.58%. The mycelia powder ofDiasporangium sp. recombinant strain D-A1 has a high nutritional value, which can prevent hyperlipemia effectively, and exhibits remarkable regulation actions to the blood lipid metabolism disorder of mice.

关 键 词：轮梗霉 营养成分 花生四烯酸 胆固醇 血脂 

分 类 号：TS222.1[轻工技术与工程—粮食、油脂及植物蛋白工程]