牛磺酸对实验性大鼠肝纤维化的预防作用  

THE PROTECTIVE EFFECT OF TAURINE ON RAT HEPATIC FIBROSIS

作　　者：李宝刚[1] 李继尧[1] 梁惠云 朱文玉[1] 

机构地区：[1]北京医科大学生理学系

出　　处：《北京医科大学学报》1998年第4期335-336,共2页Journal of Peking University(Health Sciences)

摘　　要：目的：研究牛磺酸对大鼠实验性肝纤维化的影响。方法：连续静脉注射牛血清白蛋白以制备大鼠肝纤维化模型，用比色法测定羟脯氨酸的含量，用直接红对石蜡切片中的胶原进行特异染色。结果：肝纤维化模型组中，肝的羟脯氨酸含量及肌成纤维细胞数量明显高于空白对照组，肝切片中胶原的沉积亦明显多于空白对照组。给予２５ｍｇ／ｋｇ的牛磺酸可明显降低肝的羟脯氨酸含量及肌成纤维细胞数量，肝切片中胶原的沉积亦明显减轻。结论：牛磺酸对大鼠实验性肝纤维化具有保护作用。ABSTRACT Objective: To study the effect of taurine on experimental hepatic fibrosis in rats. Methods: Successive intravenous injection of BSA to induce rat hepatic fibrosis, the contents of liver hydroxyproline were determined by chromometry, and the collagens in liver sections were observed after the specific staining with direct red 80 (Sirius red F3B). Results: The contents of liver hydroxyproline and the numbers of liver myofibroblasts in hepatic fibrotic animals were much higher than those in control animals. Furthermore, the accumulation of collagens in liver sections of hepatic fibrotic animals were also more obvious than those of control animals. Administration of 25 mg/kg taurine apparently decreased the level of liver hydroxyproline and the number of liver myofibroblasts, and the accumulation of collagens in liver sections also decreased. Conclusion: Taurine displayed a protective effect on rat experimental hepatic fibrosis.

关 键 词：肝纤维化 预防 牛磺酸 药理学 

分 类 号：R575.201[医药卫生—消化系统] R977.4[医药卫生—内科学]