BAPTA-AM的研究现状  

The research progress of BAPTA-AM

作　　者：宋必卫[1] 储昭兴[1] 

机构地区：[1]浙江工业大学药学院,浙江杭州310014

出　　处：《中国药理学通报》2009年第7期851-853,共3页Chinese Pharmacological Bulletin

摘　　要：BAPTA-AM是一前药,进入细胞后在脂酶作用下释出BAPTA,快速与Ca2+络合,控制细胞内钙水平,是研究Ca2+对细胞功能调节作用的标准工具药。BAPTA-AM对缺血缺氧下的神经细胞和细胞毒攻击下肝细胞保护作用强,并且能作用于心血管系统和呼吸系统,有望成为中风、肝功能衰竭、呼吸困难综合症等危重疾病的治疗药,具有很大的开发价值。BAPTA-AM is a standard tool agent of calcium chelating. After entering into cells, BAPTA-AM is metabolized by lipase and forms BAPTA. The latter combines with calcium ion rapidly and high selectivity. The effects of BAPTA-AM can effectively protect nerve cells against hypoxic/ischcmic injury and protect hepatocytes against cytotoxins attack. BAPTA-AM is a hopeful candidate for treating stroke, liver failure and other clinical critical diseases.

关 键 词：BAPTA-AM 细胞保护 中风 钙络合剂 细胞凋亡 钙超载 

分 类 号：R-05[医药卫生] R329.2