假肥大型肌营养不良患者肌型肌酸激酶亚型的临床研究  

A clinical study on CK MM in patients with Duchenne muscular dystrophy

作　　者：赵昕[1,2] 韩冰[1,2] 杨振华 张毅芳[1,2] 叶贤坤 赵振军[1,2] 

机构地区：[1]北京医院 [2]石家庄开发区医药研究所

出　　处：《中国康复医学杂志》1998年第4期159-161,共3页Chinese Journal of Rehabilitation Medicine

摘　　要：目的：研究假肥大型肌营养不良（ＤＭＤ）患者肌型肌酸激酶（ＣＫＭＭ）亚型的变化，为早期诊断和评价病情提供依据。方法：采用不连续缓冲体系，在稳流低压条件下电泳，将ＣＫＭＭ亚型分离、荧光扫描。结果：ＤＭＤ患者在不同阶段的ＣＫＭＭ亚型值均与对照组相比有显著性差异（Ｐ＜００５）；ＤＭＤ患者不同阶段的ＭＭ２／ＭＭ１值也有显著性差异（Ｐ＜００５）。结论：ＣＫＭＭ亚型的改变是ＤＭＤ患者诊断及判断病情的重要指标。Objective:To study the changes of isoforms of creatine kinase muscular model(CK MM) in patients with Duchenne muscular dystrophy(DMD) for the purpose of early diagnosis and evaluation.Method:A discontinuous buffer system was used.CK MM isoform was separated by electrophoresis,under constant current and low voltage,fluorescence scanning.Result:A statistically significant changes of isoforms of CK MM in each age group of subjects when compared with control group( P <0 05),and also statistically significant between the ratio of MM 2/MM 1 among these three age groups of the subjects( P <0.05).Conclusion:The ratio of MM 2/MM 1 could be considered as a special indicator of degree in the development of DMD.

关 键 词：假肥大型 肌营养不良 肌酸激酶 电泳 亚型 

分 类 号：R746.2[医药卫生—神经病学与精神病学]