磁场抑制肿瘤和影响细胞跨膜电位的探讨  

MAGNETIC FIELD INHIBITED SARCOMA AND DISCUSSION ON THE CHANGE OF THE MEMBRANE POTENTIALS

作　　者：张沪生[1,2,3,4] 杜碧[1,2,3,4] 张新晨[1,2,3,4] 李佑民[1,2,3,4] 曾繁清[1,2,3,4] 虞国寅[1,2,3,4] 姚博文[1,2,3,4] 

机构地区：[1]武汉大学物理学系 [2]武汉大学电子信息学院 [3]湖北省中医学院附属医院肿瘤科 [4]武汉大学分析测试中心

出　　处：《武汉大学学报（自然科学版）》1998年第4期506-508,共3页Journal of Wuhan University(Natural Science Edition)

基　　金：国家自然科学基金

摘　　要：峰值磁场０．６～２．０Ｔ，磁场梯度１０～１００Ｔｍ－１，脉冲宽度２０～２００ｍｓ，重复频率０．１６～１．３４Ｈｚ的磁场作用于鼠Ｓ－１８０肉瘤，在电镜下观察到肉瘤细胞程序性死亡的特征和线粒体肿胀，这一磁场能引起２．５ｍＶ的跨膜电位变化，导致Ｃａ２＋内流，促使细胞凋亡．We studied the effects of ultralow frequency plused magnetic field (with maximum intensity of 0 6～2 0 T,gradient of 10～100 T·m -1 ,pulse width of 20～200 ms and freqency of 0 16～1 34 Hz)on S 180 sarcomas in mice.With electron microscope,we found the programmed cell death (PCD) of the sarcoma cells, we also found the expanded mitochondria and the atrophied erythrocytes .we consider the mechanism is that the pulsed magnetic field causes the change of the membrane potentials,then causes the calcium ion influxin g,so leads to the programmed cell death.

关 键 词：脉冲梯度磁场 跨膜电位 磁场抑制肿瘤 细胞 

分 类 号：R730.59[医药卫生—肿瘤] Q64[医药卫生—临床医学]