应用支持向量机筛选香丹注射液的抗缺氧有效部位  

Simulation Study of Anti-hypoxia Active Fraction of Xiangdan Injection by Support Vector Machine

作　　者：陈超[1] 唐春萍[1] 沈志滨[1] 杨超燕[1] 尹永芹[1] 孙悦[1] 

机构地区：[1]广东药学院中药学院,广东广州510006

出　　处：《中药材》2009年第8期1285-1287,共3页Journal of Chinese Medicinal Materials

基　　金：国家科技支撑计划资助项目(2006BAI08B03-06);广东省科技计划资助项目(2008B030301035);广东省自然科学基金资助项目(8451022401001607);广东药学院科研启动项目(2007ZYX05)

摘　　要：目的:探讨香丹注射液的抗缺氧有效部位。方法:采用小鼠常压耐缺氧实验,基于正交设计,建立复方药效的支持向量机预测模型;并经实验验证,确定香丹注射液的抗缺氧有效部位。结果:本研究所建立的复方预测模型可以对复方不同组合进行药效预测。结论:通过模型预测和实验验证,多个配伍组的药效优于原方,尤以ADE效果最佳。Objective： To investigate the anti-hypoxia active fraction of Xiangdan injection. Methods： The anti-hypoxia experiment under normal pressure with mice was adopted on the basis of orthogonal design, and a support vector machine model was established for pharmacodynamics prediction of TCM prescriptions. Moreover, the anti-hypoxia active fraction of Xiangdan injection was determined by experimental confirmation. Results ： The prediction model established in this study could predict the drug actions of different formulas. Conclusion ： As indicated in model prediction and experimental confirmation, the phannacodynamic actions of several formulas are superior to that of the original formula, and ADE has the best effect.

关 键 词：香丹注射液 有效部位 支持向量机 模拟 

分 类 号：R284.2[医药卫生—中药学]