HIV包膜蛋白的结构及其相应的病毒进入抑制剂  

Research progress on the structure of HIV envelope glycoprotein and related HIV entry inhibitors

作　　者：夏承来[1] 姜世勃[1,2] 刘叔文[1] 

机构地区：[1]南方医科大学药学院,广东广州510515 [2]New York Blood Center, New York, NY 10065 ,USA

出　　处：《中国药理学通报》2009年第8期991-994,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No30672496,30729001);教育部新世纪优秀人才基金资助项目(NoNCET-06-0753)

摘　　要：HIV-1病毒包膜蛋白gp120和gp41在病毒感染中起着重要的作用。在病毒进入细胞的过程中,gp120先和CD4分子结合,发生构象改变,进而导致gp41构象的变化,使病毒包膜和细胞膜融合而感染细胞。与gp120或者gp41相结合的多肽、大分子和小分子化合物,都可能影响HIV-1病毒包膜和靶细胞膜结合的过程,从而起到抗HIV-1病毒的作用。该文对gp120和gp41的结构及其相互作用,以及以HIV-1包膜糖蛋白为靶点的病毒进入抑制剂类抗艾滋病药物进行综述。HIV-1 envelope glycoprotein gpl20 and gp41 are considered as two important parts in viral entry. In the process of virus entry, CD4 first binds to gpl20 and causes the conformation of gp120 to change. Furthermore the conformation of gp41 has also been changed. Many peptides, macromoleeular compounds and small molecule compounds which bind to gpl20 or gp41 can deter the progress of virus entry. These compounds can play an important role in halting the spread of HIV-1 in this way. The structure and interaction of gpl20 and gp41 are reviewed here,as well as the anti-HIV agents blocking the HIV entry by targeting the HIV-1 envelope glycoprotein.

关 键 词：HIV 包膜糖蛋白 HIV进入抑制剂 GP120 GP41 蛋白质结构 

分 类 号：R978.7[医药卫生—药品] R966[医药卫生—药学]