Weibull模型拟合细菌非线性失活曲线的应用研究  

Study on Weibull model applied in fitting non-linear inactivation curve of bacteria

作　　者：董庆利[1] 

机构地区：[1]上海理工大学医疗器械与食品学院,上海200093

出　　处：《上海理工大学学报》2009年第4期387-391,共5页Journal of University of Shanghai For Science and Technology

基　　金：国家自然科学基金资助项目(30800864);上海市教委优青专项基金资助项目(slg-07049)

摘　　要：探讨Weibull模型在拟合细菌非线性失活曲线的可行性.不同试验条件下生孢梭菌孢子从1010CFU.mL-1下降至105CFU.mL-1的热失活曲线用Weibull频数模型进行了拟合(R2>0.90).基于Weibull模型的次级模型数学检验表明,标准预测误差和平方根误差较小,准确性因子和偏差因子在可接受范围内,该模型能较好的模拟不同试验条件对生孢梭菌孢子热失活的影响,对实际产品进行验证检验后,可以推广使用.In order to study the feasibility of Weibull model used in fitting non-linear inactivation curve of bacteria,the heat inactivation curves of clostridium sporogenes spores reducing from 1010CFU·mL-1 to 105 CFU·mL-1 were fitted by Weibull frequency distribution model with R 2〉0.90.Moreover,the inactivation parameters δ and p of Weibull equations were modeled using a quadratic polynomial model.Mathematical validation demonstrates that low standard error of prediction（SEP）low root-mean-square error（RMSE）,and acceptable range of accuracy factor（A f） and bias factor（B f） can be achieved.From models based on Weibull.Weibull model provides a useful and accurate method for predicting the effect of different experimental conditions on the heat inactivation of C.sporogenes spores.

关 键 词：Weibull模型 生孢梭菌 失活曲线 

分 类 号：TS201.3[轻工技术与工程—食品科学] S431.3[轻工技术与工程—食品科学与工程]