烹饪油烟冷凝物对小鼠免疫功能的影响  

EFFECTS OF THE COOKING OIL FUME ON IMMUNE FUNCTION OF MICE

作　　者：刘志宏[1,2,3] 方浩[1,2,3] 朱玲勤[1,2,3] 姚世宏 

机构地区：[1]宁夏医学院预防医学系劳动卫生学教研室 [2]宁夏医学院附属医院统计室 [3]宁夏医学院预防医学系

出　　处：《宁夏医学院学报》1998年第3期1-3,共3页Journal of Ningxia Medical College

摘　　要：目的：了解烹饪油烟冷凝物对小鼠免疫功能的影响。方法：将６～８周龄的雌性小鼠随机分为５组，每组９只，腹腔注射烹饪油烟冷凝物，各组剂量分别为２５ｍｌ／ｋｇ、５０ｍｌ／ｋｇ、１００ｍｌ／ｋｇ、２００ｍｌ／ｋｇ，另外一组给予生理盐水（２００ｍｌ／ｋｇ）作为阴性对照，每日注射一次，共染毒６ｄ。结果：烹饪油烟冷凝物可使小鼠脾脏和胸腺等免疫器官重量减轻（Ｐ＜００１），小鼠ＤＴＨ、外周血Ｔ淋巴细胞ＡＮＡＥ阳性率受到明显抑制（Ｐ＜００１），小鼠外周血象白细胞计数及其分类中淋巴细胞百分比明显减少（Ｐ＜００１），小鼠血清抗体滴度明显降低（Ｐ＜００５或Ｐ＜００１）。Objective: To find out the effects of the cooking oil fume on immune function of mice. Methods: The mice aged 6～8 weeks were randomly divided into five groups. Each contained nine. Mice in four experimental groups were, by intraperitoneal injection, given the cooking oil fume 2.5ml/kg, 5.0ml/kg, 10.0ml/kg, 20.0ml/kg respectively and the fifth group mice were given the normal saline as negative control group. Results: The cooking oil fume could reduce the weight of immune organs(such as spleen and thymus)(P<0.01), the DTH and the ANAE positive ratio of the T lymphocyte,the amounts of white blood cells and the of lymphocyte in peripheral blood were significantly lowered(P<0.01), the titre of antibody in serum was decreased(P<0.05 or P<0.01), compared with control group. Conclusion: The cooking oil fume can inhibite the cell-mediated and humoral immune functions of the mice.

关 键 词：烹饪油烟 小鼠 免疫功能 冷凝物 油烟 

分 类 号：R126.8[医药卫生—环境卫生学]