中国一个汉族人群X染色体四个位点的多态性分析  

POLYMORPHISM ANALYSIS OF 4 LOCI OF X CHROMOSOME IN A CHINESE POPULATION OF THE HAN NATIONALITY

作　　者：窦效伟[1] 郭辰虹[1] 陈丙玺[1] 刘晓军[1] 邹雅群[1] 龚瑶琴[1] 

机构地区：[1]山东医科大学医学遗传学教研室

出　　处：《中华医学遗传学杂志》1998年第2期92-94,共3页Chinese Journal of Medical Genetics

摘　　要：目的了解中国汉族人群染色体位标的资料。方法随机选取的中国汉族７０名女性个体染色体上的ＤＸＳ１０６８、ＤＸＳ７１３２、ＤＸＳ６８０４、ＤＸＳ６７９９四个位点，应用ＰＣＲ方法进行扩增。经变性聚丙烯凝胶电泳，硝酸银染色分析等位基因多态性。结果在四个位点分别可以观察到５、５、５和６个等位基因；基因型频率观察值与预期值之间无明显差异，杂合度预期值分别为０．６８１９、０．６８９５、０．７６５９和０．６４８３，杂合度观察值与预期值之间无明显差异。结论四个位点的多态性分布资料经χ２检验，Ｐ值均大于０．０５。Objective To investigate the polymorphism of 4 loci of X chromosome in the Hans.Methods Using PCR SSLP, the authors analysed the polymorphism of DXS1068,DXS7132,DXS6804 and DXS6799 in the X chromosome in 70 randomly selected female Hans.Results The number of alleles in the 4 loci were 5,5,5,and 6 respectively; there were no significant differences between the observed and estimated and genotype probabilities of the 4 loci; the estimates of heterozygosity of 4 loci were 0.6819, 0.6895, 0.7659 and 0.6483 respectively and there were no significant differences between the observed and estimated heterozygosity of the 4 loci. Conclusion The distribution of alleles and genotype probabilities of 4 loci all observe the Hardy Weinberg equilibrium.

关 键 词：X染色体 多态性 DXS1068位点 DXS7132位点 

分 类 号：Q346.5[生物学—遗传学]