Extraction and Anti-diabetic Activity on Alloxan-induced Diabetic Mice of Polysaccharides from Huidouba  

作　　者：LIU Yan CHEN Zhao-jie LIANG Yong-tao CUI Li-yang ZHENG Dan GUO Wei-liang REN Xiao-dong Wu Yi TENG Li-rong 

机构地区：[1]College of Life Science, Jilin University, Changchun 130012, P. R. China [2]College of Pharmacy, Jilin University, Changchun 130021, P. R. China [3]Department of Endocrinology of China-Japan Union Hospital of Jilin University, Changchun 130033, P R. China

出　　处：《Chemical Research in Chinese Universities》2009年第5期681-685,共5页高等学校化学研究（英文版）

基　　金：Supported by the China Medical Foundation(No.20061108)

摘　　要：The polysaccharide extracted from Huidouba（PEH） exihibited a significant anti-diabetic activity. The polysaccharide contained glucose, mannose and galactose in a content ratio of 1.00：0.34：0.32. After administration with 50-- 200 mg/kg body weight of PEH to type II diabetic mice induced by alloxan for four weeks, the blood glucose level of mice was decreased significantly. Moreover, the SOD activity increased at the same time（p〈0.01）. PEH showed a significant anti-diabetic and anti-oxidation activity. In addition, PEH affected the BUN and ALT levels（p〈0.05）, which are important characteristics of diabetes mellitus. Through this work, PEH should be a potential anti-diabetic drug in the future.The polysaccharide extracted from Huidouba（PEH） exihibited a significant anti-diabetic activity. The polysaccharide contained glucose, mannose and galactose in a content ratio of 1.00：0.34：0.32. After administration with 50-- 200 mg/kg body weight of PEH to type II diabetic mice induced by alloxan for four weeks, the blood glucose level of mice was decreased significantly. Moreover, the SOD activity increased at the same time（p〈0.01）. PEH showed a significant anti-diabetic and anti-oxidation activity. In addition, PEH affected the BUN and ALT levels（p〈0.05）, which are important characteristics of diabetes mellitus. Through this work, PEH should be a potential anti-diabetic drug in the future.

关 键 词：HUIDOUBA POLYSACCHARIDE DIABETES HYPOGLYCEMIC 

分 类 号：TS202.3[轻工技术与工程—食品科学] S884.9[轻工技术与工程—食品科学与工程]