茶叶儿茶素对糖尿病小白鼠血糖及组织抗氧化活性的影响  

Effect of tea catechins on blood glucose and antioxidant activity in tissue of diabetic mice

作　　者：毛清黎[1,2] 孟志清[1] 杨新河[1,2] 石威[1] 毛雅慧[3] 

机构地区：[1]孝感学院生命科学技术学院,湖北孝感432100 [2]教育部茶学重点实验室,湖南长沙410128 [3]华南农业大学生命科学学院,广东广州510642

出　　处：《食品与机械》2009年第5期63-67,共5页Food and Machinery

基　　金：湖北省自然科学基金项目(编号:20002P0414);湖北省教育厅重点项目(编号:D200526004)

摘　　要：茶叶儿茶素（TC80）3种不同剂量（50，100，200mg／kg）灌胃对四氧嘧啶糖尿病小白鼠血糖水平和肝肾胰脏组织超氧歧化酶（SOD）活性及丙二醛（MBA）含量影响的试验结果表明：各剂量TC80都具有明显降糖和提高肝肾胰混合组织SOD活性作用（P〈0．01；P〈0．001），血糖值比模型组平均低6．00～9．87mmol／L，而组织SOD活性则比模型组平均高出88．33～182．70U／g；TC80对肝肾脏组织中MBA含量的降幅分别为19．47～38．19μmol／g（P〈0．01）及29．64～49．94μmol／g（P〈0．01），在各剂量处理组中只有200mg／kg高剂量组降低胰脏组织丙二醛含量的效果达显著水平（P〈0．05），比模型组低13．00μmol／g。茶叶儿茶素具有开发成新型降糖药物的前景。The experiment investigated effects of tea catechin （TC80） in three different doses（50,100 and 200 mg/kg）intragastric administration of alloxan diabetic mice on blood glucose levels and superoxide dismutase （SOD） activity and malondialdehyde （MBA） concentration of liver and kidney pancreas organizations. Experimental results showed that： Each dose of TC80 was an evident hypoglycemic and increase of SOD activity in mixture of liver-idney-pancrea organization （P〈0.01 ; P〈0. 001 ）, and blood glucose levels were an average of 6.00-9.87 mmol/L lower than the model group; while, the SOD activity in the organization was an average of 88.33 - 182.70 U/g higher than the model group; MBA content in liver and kidney tissues of all dose treatment group were respectively 19. 47 38.19 μmol/g（P〈0.01） and 29.64-49.94μmol/g （P〈0.01） lower than the model group, and only the result of 200 mg/kg in highdose groups reduced MBA content in the pancreas was significant （P〈0.05）, 13.00μmol/g lower than the model group. Tea catechin has a prospect developing into a new hypoglycemic drug.

关 键 词：茶叶儿茶素 糖尿病小白鼠 血糖 超氧歧化酶 丙二醛 

分 类 号：R285.5[医药卫生—中药学]