噻二唑硫醚双腙的合成及抗肿瘤活性  

Synthesis and antitumor activity of thiadiazolylthioether dihydrazones

作　　者：张耀洲[1] 王海燕[1] 王新[1] 毋晓魁[1] 张智强[1] 谢松强[1] 胡国强[1] 

机构地区：[1]河南大学药物研究所,河南开封475001

出　　处：《化学试剂》2009年第9期682-684,共3页Chemical Reagents

基　　金：国家自然科学基金资助项目(20872028);河南省教育厅资助项目(2007350001;2008A350001)

摘　　要：为研究杂环双腙类化合物的合成方法和抗肿瘤活性,用2-巯基-5-苯基-1,3,4-噻二唑与β-氯苯丙酮取代后与水合肼缩合得相应的单腙,然后再与芳香醛缩合得双腙目标物。7个新目标物的结构经元素分析和光谱数据确证,并用MTT实验法评价了它们的体外抗肿瘤活性。初步的药理结果表明,部分目标物对CHO、HL60、L12103种癌细胞株具有潜在的体外生长抑制活性。To study the synthesis and antitumor activity of heterocyclic dihydrazone compounds, the treatment of 2-mercapto-5- phenyl-1,3,4-thiadiazole with β-chlorophenyl-propanone formed l-phenyl-3-（ 5-phenyl-1, 3, 4-thiadiazol-2-ylsulfanyl ）-propan-1- one, followed by condensation with hydrazine hydrate and aromat- ic aldehydes to produce the corresponding mono-hydrazone and the title dihydrazone compounds, respectively. Nine new compounds were synthesized and their structures were confirmed by elemental analysis and their spectral data, and their in vitro antitumor activity against CHO, HL60 and L1210 cancer cell strains was also primarily evaluated by MTT.

关 键 词：噻二唑 双腙 合成 抗肿瘤活性 

分 类 号：O626.13[理学—有机化学]