JARID2与山东潍坊地区精神分裂症关联  

Positive association of schizophrenia to JARID2 gene in Weifang of Shandong.

作　　者：刘文敏[1] 刘阳[1] 陈刚[1] 周鹏[1] 杨树林[1] 栾萌[1] 陈星[1] 朱建平[2] 翁正[3] 

机构地区：[1]山东省医学科学院基础医学研究所医学遗传学与基因工程重点实验室,济南250062 [2]山东省潍坊市精神卫生中心 [3]山东省精神卫生中心

出　　处：《精神医学杂志》2009年第5期321-324,共4页Journal of Psychiatry

基　　金：国家自然科学基金30770780;山东省自然科学基金重点项目Z2004C10

摘　　要：目的查找精神分裂症的易感基因。方法用覆盖全基因组间隔距离10 cM(厘摩)的400个微卫星遗传标记,首先对山东省潍坊地区的119例精神分裂症患者与119例正常对照者的DNA混合样本分别进行基因组扫描,发现6号染色体上的D6S289位点基因频率在两组中差异显著,然后又对所有样本进行了逐个扫描与基因分型。结果D6S289微卫星位点的等位基因频率及基因型频率与精神分裂症呈现关联,并且此位点位于JAR-ID2基因内部。结论JAR ID2基因可能为精神分裂症的易感基因,需要对其进行深入研究。Objective To screen for susceptibility genes in schizophrenia. Methods A total of 400 microsatellite markers of the whole genome spaced at an average of 10 cM were applied to screen on two separated DNA pooling sam- ples consisting of 119 schizophrenia cases and 119 normal controls respectively. Statistic difference of allelic frequency in D6S289 on chromosome 6 was found between two pooling samples. Then samples were screened and genotyped indi- vidually. Results Significant association was found between frequency of allele and genotype on chromosome 6 at D6S289 and schizophrenia. D6S289 was located within JARIDZ gene. Conclusion JARID2 gene could be a suscepti- bility gene for schizophrenia.

关 键 词：精神分裂症 遗传 染色体 关联 D6S289 JARID2 

分 类 号：R749.3[医药卫生—神经病学与精神病学]