CD44v3和CD54在口腔黏膜癌变中的表达  

Expressions of CD44v3 and CD54 in oral premalignant epithelia

作　　者：李媛[1,2] 刘进忠[1] 郑艳丽[1] 

机构地区：[1]郑州大学口腔医学院口腔科,450052 [2]郑州市第一人民医院口腔科,450002

出　　处：《实用口腔医学杂志》2009年第5期694-697,共4页Journal of Practical Stomatology

摘　　要：目的:研究细胞黏附分子CD44v3和CD54在口腔癌前病变中的表达,揭示其在口腔癌前病变中的作用。方法:收集人正常黏膜及单纯性增生黏膜19例,上皮异常增生黏膜22例,口腔癌26例,应用免疫组化SP法检测CD44v3和CD54在正常及异常组织中的表达。结果:CD44v3和CD54蛋白在正常和单纯增生黏膜中不表达或微表达,在上皮异常增生和口腔黏膜癌中表达依次增高,3组间差异有显著性(P<0.05)。经Spearman相关性分析CD44v3和CD54蛋白染色强度与细胞增殖程度之间存在明显正相关性(P<0.05)。结论:CD44v3和CD54蛋白在口腔癌的发生发展中发挥重要作用。Objective：To investigate the expressions of CD44v3 and CD54 in oral premalignant epithelia and its significance in the carcinogenesis of oral mucosa.Methods：The expressions of CD44v3 and CD54 in 19 cases of normal mucosa and mucosal hyperplasia,22 case of dysplastic epithelia,26 cases of oral cancer mucosa were detected by using immunohistochemistry.Results：CD44v3 and CD54 proteins showed no expression or micro-expression in normal and hyperplastic epithelia.The expressions increased in the dysplastic epithelia and mucosa of oral cancer gradually.The difference between the expressions of the three groups was significant（P〈0.05）.Correlation analysis of the spearman,CD44v3 and CD54 protein staining intensity and the extent of cell proliferation significantly were correlated（P〈0.05）.Conclusion：CD44v3 and CD54 proteins play an important role in the development of oral cancers.

关 键 词：口腔癌 上皮异常增生 CD44V3 CD54 

分 类 号：R739.8[医药卫生—肿瘤]