血管紧张素原基因多态位点AGT174与原发性高血压相关性的研究  

Correlation between the Polymorphism of Angiotensinogen Gene at Position 174 and Essential Hypertension

作　　者：李少英[1] 李月秋[1] 吴雅冬[1] 罗佳滨[1] 王秀岩[1] 马继红[1] 吕学诜[1] 

机构地区：[1]黑龙江省佳木斯医学院生物教研室

出　　处：《遗传》1998年第4期18-20,共3页Hereditas（Beijing)

摘　　要：本文采用ＰＣＲ、限制性酶切和电泳分型等方法，分别对９０例原发性高血压患者和１０９例正常人血管紧张素原基因多态位点ＡＧＴ１７４进行了检测，结果表明，高血压组中三种基因型的分布与对照组显著不同，提示该位点变异与原发性高血压的发生相关。The polymorphism of angiotensinogen gene at position 174 was studied in 90 cases of essential hypertension patients and 109 controls by PCR, restriction enzyme analysis and electrophoresis methods The results showed the distribution of genetypes in hypertension group was significantly different from that of controls group This suggested there is a correlation between the variant of AGT174 and hypertension

关 键 词：多态位点 原发性 高血压 PCR AGT基因 

分 类 号：R544.102[医药卫生—心血管疾病]