家族性乳腺癌与散发性乳腺癌临床生物学特性分析  

Analysis of the clinical and molecular biological characteristics of familial and sporadic breast cancer

作　　者：陈丽芬[1] 路洪超[1] 周军[1] 高威[1] 李春晓[1] 王桂兰[1] 耿翠芝[1] 

机构地区：[1]河北医科大学第四医院外一科,石家庄050011

出　　处：《中华乳腺病杂志（电子版）》2007年第4期98-101,共4页Chinese Journal of Breast Disease(Electronic Edition)

基　　金：河北省医学适用技术跟踪项目(GL200520)

摘　　要：目的比较家族性乳腺癌与散发性乳腺癌的临床和分子生物学特性,探讨家族性乳腺癌的临床特点和预后。方法回顾性分析河北医科大学第四医院外科2005年6月至2006年5月收治的681例乳腺癌患者的临床资料,其中家族性乳腺癌18例,散发性乳腺癌663例,比较两组间临床生物学行为特点。结果家族性乳腺癌的组织学分级Ⅲ级比例(44.4%)明显高于散发性乳腺癌(17.2%),两组间差异有统计学意义(χ2=9.943,P=0.007);家族性乳腺癌的ER阴性率(50.0%)高于散发性乳腺癌(27.0%),两组间差异有统计学意义(χ2=6.203,P=0.045);家族性乳腺癌的VEGF表达阳性率(44.4%)高于散发性乳腺癌(21.9%),两组间差异有统计学意义(χ2=6.783,P=0.034)。但家族性乳腺癌和散发性乳腺癌患者在年龄分布(χ2=0.505,P=0.918),绝经状况(χ2=0.915,P=0.633),肿瘤大小(χ2=1.595,P=0.660),临床分期(χ2=1.882,P=0.597),病理类型(χ2=2.430,P=0.876),腋淋巴结转移率(χ2=0.999,P=0.607),PR(χ2=3.088,P=0.214)及C-erbB-2表达(χ2=3.094,P=0.213)等方面的差异均无统计学意义。结论家族性乳腺癌的组织学分级、ER阴性率、VEGF表达阳性率均明显高于散发性乳腺癌,提示预后较差。Objective To compare the clinical and molecular biological characteristics between familial and sporadic breast cancer, and investigate the clinical characteristics and prognosis of familial breast cancer. Methods The clinical data of 681 breast cancer patients who were treated in the Fourth Affiliated Hospital of Hebei Medical University between June 21305 and May 2006 were retrospectively analyzed, 18 of them were familial breast cancer and 663 were sporadic. The clinical biological differences were compared between the two groups. Results The comparison of familial with sporadic breast cancer patients showed the rate of histological grading Ⅲ （44.4%）, the rate of ER negative breast cancer （50.0%）, and the expression of VEGF （44.4%） were all higher in the familial breast cancer than those （ 17. 2%, 27.0%, and 21.9% ） in the sporadic breast cancer, with statistic differences [ Х^2 = 9.943, P=0. 007）, Х^2 =6.203, P =0.045）, and Х^2 =6.783, P=0.034）] respectively between the two groups. No significant differences were found in age, menopause state, tumor size, pathology type, metastatic rate of axillary lymph nodes, clinical stage, PR and C-erbB-2. Conclusion Familial breast cancer has a higher histological grading, lower expression of ER and higher expression of VEGF, which indicates a bad prognosis.

关 键 词：乳腺肿瘤 家族性 生物学行为 

分 类 号：R737.9[医药卫生—肿瘤]