脑胶质瘤中β-catenin和细胞周期素D1表达的意义  

Significance of β-catenin and Cyclin D1 express in glioma

作　　者：张志强[1] 陈红庆[1] 陈映红[1] 程新富[1] 

机构地区：[1]解放军第161中心医院神经外科,湖北武汉430010

出　　处：《细胞与分子免疫学杂志》2009年第11期1010-1012,共3页Chinese Journal of Cellular and Molecular Immunology

摘　　要：目的:研究β-catenin与Cyclin D1蛋白在脑胶质瘤的表达及其意义。方法:应用免疫组织化学SABC法检测49例脑胶质瘤组织和5例正常脑组织中β-catenin和Cyclin D1的蛋白表达。男30例,女19例,年龄12～75岁,平均42.56岁。结果:在正常脑组织和脑胶质瘤中,β-catenin蛋白阳性的比例分别为2/5和38/49(P<0.01),Cyclin D1蛋白阳性的比例分别为1/5和42/49(P<0.01);比较β-catenin和CyclinD1在脑组织、低级别脑胶质瘤和高级别脑胶质瘤中的光密度值,发现发现各组之间均存在着统计学差异(P<0.05或P<0.01);β-catenin的过度表达与Cyclin D1的过度表达显著相关(r=0.6395,P<0 05)。结论:脑胶质瘤细胞β-catenin与Cyclin D1表达增强,可能参与胶质瘤的发生。AIM： To investigate the expression and the significance of β-catenin and Cyclin D1 in gliomas. METHODS： The SABC immunohistochemistry were used to detect the expression of β-catenin and Cyclin D1 in 49 brain gliomas and 5 normal brain tissues. RESULTS： The β-catenin positive ratio in normal brain tissues and glioma samples are 2/5 and 38/49 （ P 〈 0.01 ） respectively, and the Cyclin D1 positive ratio in normal brain tissues and gliomas are 1/5 and 42/49（ P〈0.01 ） ; Compared with the normal brain tissue, both the immunohistochemical expression of β-catenin and Cyclin D1 were up-regulated （ P 〈 0.05 ）, and the expression of β-catenin and Cyclin D1 between the normal brain tissues and gliomas exhibited significantly difference （P〈 0.01）. CONCLUSION： β-catenin and Cyclin D1 increased in gliomas may be precipitate the tumorigenesis of glioma.

关 键 词：脑胶质瘤 Β-CATENIN CYCLIN D1 免疫组化 

分 类 号：R735.2[医药卫生—肿瘤] R739.41[医药卫生—临床医学]