灰树花多糖对糖尿病小鼠的降血糖作用  

Glucose-lowering effect of Grifola frondosa polysaccharides on experimental diabetic mice

作　　者：周伟[1] 奚清丽[1] 石根勇[1] 

机构地区：[1]江苏省疾病预防控制中心,江苏南京210009

出　　处：《江苏预防医学》2009年第4期17-20,共4页Jiangsu Journal of Preventive Medicine

摘　　要：目的:观察灰树花多糖(GFP)对糖尿病小鼠(DM)的血糖调节作用。方法:将四氧嘧啶按180 mg/kg b.wt.剂量腹腔内1次性注射制作糖尿病小鼠模型。实验组分别按750、250、125mg/kg b.wt.三个剂量每天灌服GFP,正常对照组和实验对照组每日灌服相应体积的水,实验周期均为40 d。尾静脉采血测小鼠血糖值及糖耐量实验。结果:喂养40 d后,250 mg/kg.b.wt.剂量组与实验对照组比较,血糖水平和血糖曲线下面积均明显降低(P<0.05),750和125 mg/kg b.wt.剂量组与实验对照组比较无明显降低(P>0.05)。结论:灰树花多糖具有降低实验性糖尿病小鼠血糖的作用。Objective： To study the effects of Grifola frondosa polysaccharides（GFP） on regulating blood glucose in diabetic mice（DM）. Methods： The model of experimental diabetic mice was established by abdominal cavity injection of alloxan with the dose of 180mg/kg. The animals were orally administered with GFP in the doses of 750,250,125 mg/kg, b. wt. , respectively, for 40 days. Blood was collected from the tail vein. The level of blood glucose was determined with the method of glucose eoxidase. Results： After hypoglycemic mice were fed GFP 750,250,125 mg/kg, b. wt for 40 days, the glucose level and the area under glucose curve did not reduce significantly in both 750mg/kg. b. wt group and 125 mg/kg, b. wt group （P〉0. 05） ,but which in 250 mg/kg, b. wt group was reduced obviously compared with the control（P〈0. 05）. Conclusion GFP can reduce the level of blood glucose in experimental diabetic mice.

关 键 词：灰树花多糖 糖尿病 小鼠 降血糖 

分 类 号：R-331[医药卫生]