计算机辅助立体定向hRPE细胞脑内移植治疗帕金森病临床研究  

Computer Assisted Stereotactic Transplantation of Human Retinal Pigmeat Epithelium Cells in Pakinson's Disease

作　　者：薛彦忠[1] 任廷文[2] 庞守良[1] 王玉国[1] 姚金国[1] 周建峰[1] 郝培来[1] 徐会厂[1] 

机构地区：[1]山东省临沂市沂水中心医院神经内科,山东临沂276400 [2]中山医科大学附属医院,广东广州510000

出　　处：《河北医学》2009年第12期1387-1390,共4页Hebei Medicine

摘　　要：目的:探讨人视网膜色素来源上皮细胞定向移植治疗帕金森病的临床疗效。方法:在CT和MR I图像融合技术指导下,将4×106hRPE细胞通过立体定向手术移植到症状对侧的壳核后部和侧脑室内,共17例患者。结果:移植术后对侧症状持续改善,3月时总有效率达88.2%,显效率为82.4%;同侧症状于术后即有改善者,1月后改善率即明显增加,3月时总有效率达88.2%,显效率为64.7%。除少数患者有一过性头晕和肢体轻瘫外,无其他重大不良反应。结论:计算机辅助立体定向手术移植hRPE细胞治疗PD安全、有效。Objective： To explore the efficacy and safety of computer assisted stereotacfic transplantation of human pigmeat epithelium （ hRPE ） cells on parkinson＇ s disease （ PD ）. Method： With the guidence of CT and MRI image mergence,we transplanted 4×10^6 hRPE cells into the putamen and ventriculus laterlis of 17 cases PD by stereotactic surgery. The transplantation site were located in the contralateral side of the symptoms and signs . Result： After 3 months follow-up, the effective rate of cell transplantation was 82.4% in the contralateral site and 64.7% in the ipsilateral site. Only a minority of cases had mild dizziness and hemiparesis, but the duration was short. Conclusion： The therapy, computer assisted stereotactic transplantation of hRPE in the treatment of PD, is safe and efficient.

关 键 词：hRPE 立体定向技术 细胞移植 图像融合 帕金森病 

分 类 号：R742.5[医药卫生—神经病学与精神病学]