谷氨酸棒杆菌合成生物絮凝剂分批发酵过程的动力学模拟  

Kinetic models for bioflocculant fermentation from Corynebacterium glutamicum

作　　者：安仲涛[1] 李清彪[1] 何宁[1] 陈仁彬[1] 江新德[1] 杨坤[1] 

机构地区：[1]厦门大学化学化工学院化学工程与生物工程系,福建厦门361005

出　　处：《化工学报》2009年第12期3071-3076,共6页CIESC Journal

基　　金：国家自然科学基金项目(30700020);厦门市科技计划项目(3502Z20093006)~~

摘　　要：对谷氨酸棒杆菌生产生物絮凝剂的分批发酵过程进行了动力学研究。以Logistic方程来描述菌体生长过程,并对Gaden生长相关模型进行了修正,加入时间修正因子,建立了产物生成动力学模型,同时还提出了关于葡萄糖和尿素的两个非线性基质消耗动力学模型。利用软件Origin8.0对实验数据进行拟合,结果显示各模型均能较好地描述谷氨酸棒杆菌合成生物絮凝剂的分批发酵过程。Kinetic models were developed for the batch fermentation of bioflocculant from Corynebacterium glutamicum. Logistic equation and time-corrected modified Gaden＇s growth-associated model were used to describe the cell growth and the bioflocculant synthesis, respectively. Two kinetic models in the format of non-linear equations were proposed to predict the consumption of glucose and urea. Curve fittings for the above models by using experimental data were performed with the software Origin 8. 0. The results showed that the four models proposed in the work could well characterize the batch culture of C. glutamicum in bioflocculant production.

关 键 词：谷氨酸棒杆菌 生物絮凝剂 分批发酵 动力学 

分 类 号：TQ922.9[轻工技术与工程—发酵工程] TS261.43