首发精神分裂症患者N400神经发生源的研究  

Study on neural generators of N400 in first episode schizophrenia

作　　者：陈兴时[1] 唐云翔[2,3] 肖泽萍[4] 王继军[5] 张明岛[1] 张载福 胡珍玉 陈中鸣 楼翡璎[1] 陈冲[1] 杨杰[1] 

机构地区：[1]上海交通大学医学院上海市精神卫生中心神经生理室,上海200030 [2]第二军医大学心理学教研室,上海200433 [3]上海交通大学医学院上海市精神卫生中心,上海200030 [4]上海交通大学医学院精神科,上海200030 [5]上海交通大学医学院脑电影像室,上海200030 [6]浙江省金华市第二医院精神科,金华321016 [7]浙江省宁波市康宁医院精神科,宁波315201

出　　处：《上海交通大学学报（医学版）》2009年第11期1351-1354,共4页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家自然科学基金(30770772, 30971046);国家高技术研究发展计划(“863”计划)(2008AA02Z412,2007AA02Z420);上海市科学技术委员会2007年创新行动计划(7411950)~~

摘　　要：目的探讨首发精神分裂症患者汉语句子结尾词匹配和非匹配事件相关脑电位(ERP)N400的特点及其神经发生源。方法应用WJ-1型ERP仪,对56例首发精神分裂症患者使用76个汉语句子(31句匹配,45句非匹配)进行刺激,诱发N400,经脑地形图分析软件对N400差异波105～615ms时间窗口内的神经发生源进行研究。结果①在首发精神分裂症患者中,语义非匹配较语义匹配的N400潜伏期长,波幅高(P<0.05或P<0.01);②汉语句子诱发的N400广泛分布于脑部各区,N400波型明显。③N400在345～405ms时,主要激活额区;在420～570ms时,可激活多个脑区,以中央区激活最显著。结论首发精神分裂症患者汉语句子N400神经发生源可能是多源性、多部位共同作用的结果,以额区最为活跃。Objective To explore the features and neural generators of the events related potentials （ERP） component N400,elicited by congruent and incongruent ending sentences,in first episode schizophrenia patients. Methods N400 was elicited by 76 congruent （31） or incongruent （45） ending Chinese sentences paradigm,and recorded by WJ-1 ERP instruments in 56 first episode schizophrenia. The neural generators of N400 different wave in 105-615 ms time windows were analyzed by Brain Electrical Activity Mapping software. Results ① The N400 latencies were significantly longer and amplitudes significantly higher in incongruent conditions than in congruent conditions in first episode schizophrenia （ P 0.05 or P 0.01）. ② N400 elicited by Chinese sentences distributed on frontal,parietal,occipital and temporal regions,and had a clear waveform. ③ The main brain areas activated by N400 were frontal areas in 345-405 ms time windows,and central areas in 420-570 ms time windows. Conclusion N400 elicited by Chinese sentences are multi-generated in first episode schizophrenia,especially in frontal area.

关 键 词：精神分裂症 N400 神经发生源 事件相关脑电位 汉语句子 脑地形图 

分 类 号：R749.3[医药卫生—神经病学与精神病学]