普洱茶对非酒精性脂肪肝保护作用  

Protecive effects of Pu-erh tea on nonalcoholic fatty liver in rats

作　　者：侯艳[1] 肖蓉[2] 徐昆龙[2] 邵宛芳[1] 田洋[3] 

机构地区：[1]云南农业大学龙润普洱茶学院,昆明650201 [2]云南农业大学动物科学技术学院 [3]云南农业大学食品科学技术学院

出　　处：《中国公共卫生》2009年第12期1445-1447,共3页Chinese Journal of Public Health

基　　金：国家科技支撑计划课题(2007BAD58B04);农业部现代农业产业技术体系建设专项资金资助项目

摘　　要：目的探讨普洱茶对高脂饮食诱发的大鼠非酒精性脂肪肝的保护作用。方法将SD大鼠分为正常对照组、高脂模型组以及普洱生茶、普洱熟茶低、中、高剂量[0.5,1.5,3.0 g/(kg.bw)]组。试验30 d后处死大鼠,制作病理切片,测定其血清中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性和丙二醛(MDA)及胆固醇(TC)含量。结果中、高剂量普洱生茶和熟茶组血清中SOD活力分别为(198.82±52.83),(224.07±22.9),(191.63±14.75),(245.22±13.64)U/mL,均明显高于高脂模型组的(152.33±11.77)U/mL;GBH-Px活性明显升高,MDA和TC含量明显降低,与高脂模型组比较,差异均有统计学意义(P<0.05);通过大体标本和病理检测发现,中、高剂量普洱生茶和熟茶能明显改善由高脂饮食引起的肝脏脂肪变性。结论普洱茶能有效抑制高脂饮食诱发脂质过氧化反应对SD大鼠肝组织损伤,对非酒精性脂肪肝有明显保护作用。Objective To evaluate protective effects of Pu-erh teas on high-fat diets induced nonalcoholic fatty liver in SD rats.Methods Eighty SD rats were divided into groups of normal control,model of high-fat diet,Pu-erh raw tea or Pu-erh mature tea treated groups（0.5,1.5,and 3.0 g/kg·bw,repectively）.All rats were sacrificed after 30 days＇ test feeding.Biochemical parameters including superoxide dismutase（SOD）,glutathion peroxidase（GSH-PX）,malondialdehyde（MAD） and total cholesterol（TC） in blood serum were determined,and pathological changes of the liver were observed.Results With different dose of Pu-erh tea,hepatic steatosis were improved in dose-response and dose-dependent manner.The activity of SOD,GSH-PX in blood increased significantly,and the level of MDA and TC decreased significantly（P〈0.5）.Conclusion Pu-erh tea could suppress oxidative stress-lipid peroxidation in liver cells,and improve the pathological damages of liver effectively.The fatty liver was improved by reducing the lipid deposition and oxidative damage,which may be the mechanism of the effects of Pu-erh tea.

关 键 词：脂肪肝 普洱茶 脂质过氧化 

分 类 号：R575.5[医药卫生—消化系统]