茶多酚对1-甲基-4-苯基-1-2-3-6-四氢吡啶帕金森病小鼠模型细胞因子的影响  

Impact of Tea Polyphenol on the Cytokine in MPTP-induced Mouse Model of Parkinson's Disease

作　　者：吕志坤[1] 邵蓓[1] 张扬[1] 宋兴伟[2] 黄学荪[3] 王群姬[4] 徐惠琴[1] 牛晓婷[1] 

机构地区：[1]温州医学院附属第一医院脑科中心,325000 [2]温州医学院附属第二医院神经科,325027 [3]温州医学院附属第一医院药剂科,325000 [4]温州医学院附属第一医院病理科,325000

出　　处：《中国临床神经科学》2009年第6期585-590,621,共7页Chinese Journal of Clinical Neurosciences

基　　金：温州市科技局项目(编号Y2005A116)

摘　　要：目的:观察和探讨茶多酚对1-甲基-4-苯基-1-2-3-6-四氢吡啶(MPTP)帕金森病(PD)小鼠模型的细胞因子分泌的影响及茶多酚对PD神经元保护的作用机制。方法:采用C57BL小鼠腹腔注射MPTP复制PD模型,观察茶多酚对PD模型多巴胺神经元的保护作用。结果:PD模型组与茶多酚保护组比较PD模型小鼠爬杆时间明显缩短,黑质酪氨酸羟化酶阳性细胞显著增多,纹状体内IL-6含量增高,TNF-α因子变化不明显。结论:茶多酚对MPTP-PD模型小鼠的多巴胺神经元具有保护作用,其保护作用机制可能与影响IL-6的分泌有关。Aim： To observe the protective effects of the tea polyphenol （TP） on the change of cytokine in substantia concomitant with a depletion of dopamine of corpus striatum in 1-methy-4-phenyl-l,2,3,6- tetrahydropyridine（MPTP）-induced mouse model of Parkinson＇s disease（PD）. Looking for the protection mechanism of tea polyphenol on the PD＇ s dopamine neuron. Methods： Using the CBL57 mouse abdominal cavity to inject MPTP to duplicate the PD model, to observe the protective function of tea polyphenol to the PD model dopamine neuron. Results： Compared with the group of MPTP, the climbing time of prevention group reduced obviously, the tyrosine hydroxylase（TH） positive cell obviously increased, and the plasma levels of IL-6 decreased, but the changes of TNF-a were not evident. Conclusion： Tea polyphenol can protect the dopamine neurons from loss in MPTP-induced mice, its protective effect possible with to affect the secretion of IL-6 to concern.

关 键 词：帕金森病 茶多酚 1-甲基-4-苯基-1 2 3 6-四氢吡啶 

分 类 号：R742.5[医药卫生—神经病学与精神病学]