山楂叶提取物自微乳化释药系统的降血脂作用  

Antilipidemic Effects of Self-Microemulsifying Drug Delivery System of Hawthorn Leaves Extract

作　　者：崔升淼[1] 赵春顺[2] 

机构地区：[1]广东药学院,广东广州510006 [2]中山大学,广东广州510006

出　　处：《时珍国医国药》2009年第12期2989-2990,共2页Lishizhen Medicine and Materia Medica Research

基　　金：广东省科技计划项目(No.2007B060401058);广东省中医药局建设中医药强省科研项目(No.2008172)

摘　　要：目的研究山楂叶提取物自微乳化释药系统的降血脂作用。方法通过高脂饲料喂养,造成大鼠高血脂模型,经给予山楂叶提取物自微乳化释药系统后,测定血脂变化。结果山楂叶提取物自微乳化释药系统能明显降低高血脂大鼠的血清甘油三酯、总胆固醇和低密度脂蛋白。结论山楂叶提取物自微乳化释药系统有明显降低大鼠高血脂的作用。Objective To study the antilipidemic effect of self - microemulsifying drug delivery system of hawthorn leaves extract. Methods Hyperlipedemic animal models induced by high - fat feed were employed to investigate the antilipidemic effect of S - SMEDDS. Results S -SMEDDS could reduce the level of TG, TC and LDL -C. Conclusion The serum lipid level of hyperlipedemic rat can be decreased significantly by S- SMEDDS.

关 键 词：山楂叶提取物 自微乳化释药系统 降血脂 

分 类 号：R285.5[医药卫生—中药学]