肝细胞癌mdr1基因编码的P-糖蛋白的表达意义  

Expression of mdrl genecoded P-glycoprotein in hepatocellular carcinoma and its clinical significance

作　　者：许炳华[1] 张瑞菊[1] 陆东东[1] 陈旭东 王能进[1] 

机构地区：[1]江苏省启东市肝癌防治研究所

出　　处：《华人消化杂志》1998年第9期783-785,共3页

摘　　要：目的探讨ｍｄｒ１基因编码的Ｐ糖蛋白（Ｐｇｐ）在肝细胞癌（ＨＣＣ）及癌周正常肝组织中的表达及其临床意义．方法用免疫组化ＳＡＢＣ法，检测３９例ＨＣＣ及３０例癌周肝组织中Ｐｇｐ表达，分析ＨＣＣ中Ｐｇｐ表达程度和肿瘤主要临床病理特征间的关系．结果Ｐｇｐ表达主要位于肝、肝癌及胆管上皮细胞膜上，少量位于胞质内；肝组织中平均Ｐｇｐ阳性率（５６４％）明显高于癌组织（２６０％，ｕ＝２６５，Ｐ＜００１）；经治病例癌组织Ｐｇｐ表达均在５０％以上；癌组织Ｐｇｐ表达仅和细胞分化有关（χ２＝５８６，Ｐ＜００５）．结论肝脏是内源性耐药器官；经治后肝癌耐药性增强；IM To explore the expression and clinical significance of P-glycoprotein (Pgp) in hepatocellular carcinoma (HCC) and its surrounding liver tissues.METHODS Abstract:The expression of Pgp in 33 cases of HCC tissues and 30 surrounding normal liver tissues was detected with immunohistochemical SABC. The relationship between Pgp expression in HCC tissues and clinicopathological features of the tumors were also analyzed.RESULTS Pgp mainly lied on the membrane of normal hepatocytes, carcinoma and biliary duct cells and a few in plasma. Pgp positive rate in liver tissues was significantly higher than that in carcinoma tissues on average (564% vs 260%, u=265,P<001). The positive rate of Pgp in tumor tissue after treatment was over 50%. The expression of Pgp in carcinoma tissues was only related to tumor cell differentiation (χ2=587,P<005).CONCLUSION Liver is an intrinsic drugresistance organ, and the drugresistance of hepatocellular carcinoma was enhanced after treatment. A reasonable chemotherapy protocol should be selected.

关 键 词：肝肿瘤 遗传学 病理学 糖蛋白类 

分 类 号：R735.702[医药卫生—肿瘤]