氨哮素防治失神经骨骼肌萎缩的临床研究  

The clinical trial of the effects of clenbuterol on retarding denervation induced muscle atrophy

作　　者：姜广良[1] 顾玉东[1] 张丽银[1] 徐建光[1] 沈丽英[1] 张凯莉[1] 

机构地区：[1]上海医科大学华山医院手外科

出　　处：《中华手外科杂志》1998年第3期164-166,共3页Chinese Journal of Hand Surgery

基　　金：美国中华医学基金;上海市医学领先学科;国家自然科学基金;卫生部重点学科基金

摘　　要：目的临床研究应用氨哮素防治失神经骨骼肌肌萎缩的效果及副作用。方法随机选用双盲安慰剂对照的研究方法，对７１例因臂丛神经损伤而致肱二头肌完全失神经支配的患者，服用氨哮素（６０μｇ，每日２次）３个月。采用肌电图，肌肉ＡＴＰ酶组织化学染色，肌动蛋白、肌球蛋白免疫组织化学染色等检测手段，分别检测用药前后肱二头肌纤颤电位、肌纤维面积和收缩蛋白含量的变化。并观察患者用药前后心、肺、肝、肾及出凝血功能的变化。结果氨哮素对失神经肱二头肌纤颤电位的衰减、Ｉ型和ＩＩ型肌纤维面积的萎缩、肌动蛋白丧失的抑制率分别为３００％、６６％、６０％和５０％（Ｐ＜０．０５）。对心、肺、肝、肾及出凝血功能均无明显影响。Objective To investigate the clinical effects of clenbuterol on delaying denervated muscle atrophy and its adverse effects. Methods This was a randomized, double blind and placebo controlled study. Clenbuterol with a dosage of 60μg/Bid for more than 3 months was administered in 71 patients with complete denervation of biceps brachii muscles due to brachial plexus injuries. The changes of fibrillation potential amplitude, myofiber cross sectional areas and contents of contractive proteins were measured by electromyography , ATPase histochemical stain, actin and myosin immunohistochemical stains of the biopsied muscles before and after clenbuterol administration respectively .The changes in the functions of heart,lung,liver,kidney and blood coagulation were also observed. Results The inhibition rates on fibrillation potential amplitude reduction,type I and II fiber atrophy and the actin content loss were 300%,66%,60% and 50% respectively ( P <0.05); there was no side effects on the functions of heart,lung,liver,kidney and blood coagulation. Conclusions Clenbuterol is a powerful,safe and long effective drug in retarding denervation induced muscle atrophy and can be used in clinical practice.

关 键 词：肾上腺素能Β激动剂 肌.骨骼 肌萎缩 去神经支配 

分 类 号：R746.4[医药卫生—神经病学与精神病学]