巨细胞病毒肝炎婴儿血浆肠血管活性多肽测定的意义  

Clinical Significance of Plasma Vasoactive Intestinal Polypeptides Level Detection in Cytomegalovirus Hepatitis

作　　者：杨辉[1] 金玉[1] 郝理华[1] 李玫[1] 何祖慧[1] 

机构地区：[1]南京医科大学附属南京儿童医院消化内科,南京210008

出　　处：《实用儿科临床杂志》2009年第22期1720-1721,1725,共3页Journal of Applied Clinical Pediatrics

基　　金：南京医科大学科技发展基金面上项目资助(08NMUM039)

摘　　要：目的观察巨细胞病毒(CMV)肝炎婴儿血浆肠血管活性多肽(VIP)水平,探讨其与肝损害、胆汁淤积及胆道闭锁的关系。方法将2008年8月-2009年5月南京儿童医院收治的62例CMV肝炎婴儿分为肝炎组13例(男8例,女5例),瘀胆组15例(男8例,女7例),肝胆组20例(男11例,女9例),胆道闭锁组14例(男7例,女7例)。健康对照组14例,男8例,女6例。母乳性黄疸组15例,男7例,女8例。放射免疫法测定各组CMV肝炎患儿及母乳性黄疸患儿和健康婴儿血浆VIP水平。结果肝炎组患儿血浆VIP水平为(61.75±8.30)ng/L,高于健康对照组[(41.83±9.30)ng/L](P<0.05);瘀胆组患儿血浆VIP水平为(63.73±3.54)ng/L,显著高于健康对照组(P<0.01);而母乳性黄疸组患儿血浆VIP水平(35.16±10.14)ng/L与健康对照组比较无显著性差异(P>0.05);肝胆组患儿血浆VIP水平[(53.62±4.00)ng/L]显著高于健康对照组(P<0.05);胆道闭锁组患儿血浆VIP水平为[(20.27±9.00)ng/L]显著低于健康对照组(P<0.01)。结论血浆VIP水平增高既是CMV肝炎患儿肝损害的结果,又是促进胆汁瘀积的原因。增加胆道闭锁患儿血浆VIP水平,可能通过抑制肝胆自身免疫反应,减轻肝胆系统损伤,具有潜在的治疗价值。Objective To observe the plasma vasoactive intestinal polypeptide （VIP） concentration in infants with eytomegalovirus （CMV） hepatitis and to explore the correlation between plasam VIP level and liver injury,cholestasis or biliary atresia. Methods Sixty - two infants with CMV hepatitis in Nanjing children＇s hospital from Aug. 2008 to May 2009 were divided into 4 groups, in which hepatits group con- tained 13 eases （male 8 cases ,female 5 cases）, cholestasis group contained 15 cases （male 8 cases, female 7 cases）, hepatitis and cholestasis group contained 20 cases （male 11 cases,female 9 cases） ; and biliary atresia group contained 14 cases （ male 7 cases,female 7 cases）. Healthy control group contained 14 cases （male 8 cases,female 6 cases）. Breast milk jaundice group contained 15 cases （male 7 cases, fe- male 8 cases）. The plasma VIP concentrations of infants with CMV hepatitis,and breast milk jaundice ,healthy infants （ healthy control group） were measured by using radioimmunoassay. Results VIP concentration in plasma of infants in hepatitis group [ （61.75 ± 8.30） ng/L] was higher than that in healthy control group [ （41.83 ± 9.30 ） ng/L P 〈 0.05 ] ; VIP concentration in plasma of infants in cholestasis group [ （63.73 ± 3.54） ng/L] was obviously higher than that in healthy control group （ P 〈 0.01 ）. And there was no significant difference between breast milk jaundice group and healthy control group [ （35.16 ± 10.14） ng/L P 〉 0.05 ]. The concentration of plasma VIP in hepatitis and cholestasis group [ （53.62 ± 4.00） ng/L 1 was significantly higher than that in healthy control group （ P 〈 0.05 ） ;The plasma VIP concentra- tion in biliary atresla group[ （20.27 ＋9.00） ng/L] was significantly less than that in healthy control group （P 〈 0.01）. Conclusions In- creased plasma VIP level is the result of liver injury and also the reason of promoting the formation of cholestasis in infants with CMV hepatitis. Increased plasma VIP l

关 键 词：肝炎 巨细胞病毒 肠血管活性多肽 婴儿 

分 类 号：R725.1[医药卫生—儿科]