木糖醇作为渗透泵制剂新辅料的双重作用研究  

Diphasic function of xylitol in osmotic pump preparations as a novel excipient

作　　者：张志宏[1] 孙光美[1] 杨星钢[1] 彭博[1] 李宁[1] 潘卫三[1] 

机构地区：[1]沈阳药科大学药学院,沈阳110016

出　　处：《中国新药杂志》2009年第23期2264-2268,共5页Chinese Journal of New Drugs

摘　　要：目的:考察木糖醇作为渗透泵制剂新辅料的可行性。方法:考察木糖醇的稳定性及其对药物测定的干扰;分别制备单层渗透泵(EOP)和推拉式渗透泵(PPOP),木糖醇作为促渗剂及致孔剂,并与常用促渗剂和致孔剂比较。结果:木糖醇只在远紫外处有较弱吸收,不易干扰药物的测定;除在强酸和强氧化性条件下以外木糖醇性质稳定;木糖醇的促渗作用与氯化钠相当,调节木糖醇用量可以达到与聚乙二醇(polyethylene glycol,PEG)相同的致孔作用。结论:木糖醇可作为促渗剂及致孔剂用于渗透泵制剂。Objective： To discuss the feasibility of the application of xylitol in osmotic pump preparation. Methods ： The stability and the interference of xylitol on the determination of target compound were tested. Elementary osmotic pump（EOP） and push-pull osmotic pump（PPOP） were prepared using xylitol as a penetrating agent and a channel agent. The dissolution behavior of xylitol was compared with the osmotic pump tablets using NaCl as a penetrating agent and PEG as a channel agent. Results：Xylitol was stable except in strong acidic and oxygenic surrounds,which just had a weak UV absorption in short wavelength, thus it did not disturb the measurement of drugs. The penetrating ability of xylitol was as good as NaCl. The ability of xylitol as a channel agent was the same as PEG with an appropriate switch of the amount. Conclusion ：Xylitol could be used in osmotic pump preparations as a penetrating agent and a channel agent.

关 键 词：木糖醇 渗透泵 促渗剂 致孔剂 盐酸二甲双胍 格列吡嗪 

分 类 号：R943.41[医药卫生—药剂学] R977.15[医药卫生—药学]