Y-IP5对小鼠吗啡行为敏化和条件性位置偏爱的影响  

Effects of Y-IP5 on morphine-induced behavioral sensitization and conditioned place preference in mice

作　　者：许月芳[1,2] 苏瑞斌[2] 杨日芳[2] 吴宁[2] 路新强[2] 李锦[2] 

机构地区：[1]解放军总医院第一附属医院药剂科,北京100048 [2]军事医学科学院毒物药物研究所,北京100850

出　　处：《中国药理学通报》2009年第12期1578-1583,共6页Chinese Pharmacological Bulletin

基　　金：国家高科技研究发展计划(863计划)资助项目(No2003CB515400);国家自然科学基金资助项目(No30472017)

摘　　要：目的探讨新型化合物Y-IP5对吗啡诱导小鼠行为敏化和条件性位置偏爱(conditioned place preference,CPP)的影响。方法测定小鼠的自发活动,观察Y-IP5对小鼠自发活动及急性给予吗啡所诱导小鼠高活动性的影响;慢性吗啡处理小鼠,建立小鼠吗啡行为敏化和CPP模型,观察Y-IP5对行为敏化形成、转化、表达及CPP形成的影响。结果单次或多次给予Y-IP5都不影响小鼠的自发活动,但能抑制急性给予吗啡所致的小鼠高活动性(P<0.05);Y-IP5本身不诱导小鼠形成行为敏化和CPP,但能抑制吗啡诱导小鼠形成行为敏化和CPP(P<0.05),但Y-IP5对吗啡诱导小鼠行为敏化的转化和表达无抑制作用。结论Y-IP5对阿片类药物的精神依赖可能具有干预作用。Aim To investigate the effects of Y-IP5 on morphine-induced behavioral sensitization and CPP in mice.Methods Locomotor activity was detected after Y-IP5 administration or co-administration of Y-IP5 with morphine in mice.Mice were treated with morphine to induce behavioral sensitization.Then the effects of Y-IP5 on the development,transfer and expression of morphine-induced behavioral sensitization were investigated.Mice were treated with morphine to induce CPP.Then the effect of Y-IP5 on the acquisition of morphine-induced CPP was studied.Results Y-IP5 itself didn＇t influence locomotor activity of mice.Co-administration of Y-IP5 with morphine inhibited morphine-induced hyperactivity （P〈0.05） and the development of morphine-induced behavioral sensitization in mice （P〈0.05）,however,did not influence the transfer and expression of morphine-induced behavioral sensitization.Co-administration of Y-IP5 with morphine also inhibited the acquisition of morphine-induced CPP （P〈0.05）.Conclusion Y-IP5 may inhibit the psychological dependence induced by morphine.

关 键 词：Y-IP5 NMDA NR2B 吗啡 行为敏化 条件性位置偏爱 

分 类 号：R-332[医药卫生] R392.11