食管、贲门癌组织中P53基因蛋白过度表达及其生物学意义  

Overexpression of P53 Geneprotein and Its Biologic Importance in Esophageal and Cardiac Carcinoma

作　　者：吴铭生[1] 邹雅群[1] 王善政[1] 张建平[1] 

机构地区：[1]山东医科大学附属医院

出　　处：《中国胸心血管外科临床杂志》1998年第3期149-150,共2页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

摘　　要：目的研究食管癌、贲门癌组织中Ｐ５３基因蛋白表达情况及其意义。方法采用免疫组织化学ＡＢＣ法检测了６０例食管癌、贲门癌组织中Ｐ５３基因蛋白表达情况，并结合肿瘤的某些病理特点如分化程度、ＴＮＭ分期等进行了分析。结果Ｐ５３基因蛋白过度表达的阳性率高分化组（７５％）与中（９６．９％）、低（１００％）分化组之间差异显著（Ｐ＜０．０１）。食管癌，Ⅱ期与Ⅲ期的Ｐ５３基因蛋白过度表达的阳性率分别为９５．７％和９２．３％；贲门癌，Ⅰ期、Ⅱ期、Ⅲ期阳性率分别为６６．７％、１００％和９３．３％，经检验，食管癌、贲门癌组织中Ｐ５３基因蛋白过度表达与肿瘤ＴＮＭ分期之间无差异（Ｐ＞０．０５）。结论随着肿瘤分化程度的降低，Ｐ５３基因蛋白过度表达的阳性率将增高，Ｐ５３基因蛋白有可能成为判断食管癌、贲门癌恶性程度的指标之一；ｐ５３基因突变及Ｐ５３基因蛋白过度表达不仅出现在食管癌、贲门癌发生、发展的晚期阶段，而在早期阶段就已存在并起作用。Objective Try to find the importance of P53 geneprotein overexpression as a tumor symbol in esophageal and cardiac carcinoma. Methods With the immunohistochemical ABC assay, some pathological features such as the degree of cell differentiation, TNM stage, et al were analyzed according to the overexpression of P53 geneprotein of 60 specimens of esophageal and cardiac carcinoma. The data were statistically analyzed by chisquare test and exact probabilities. Results There was an obvious statistical correlation between the degree of cell differentiation and the overexpression of P53 geneprotein (P<0.01), but no obvious statistical correlation between the TNM stage and the overexpression of P53 geneprotein (P>0.05). Conclusion P53 geneprotein may be regarded as an useful index in determining the malignant degree of esophageal and cardiac carcinoma. p53 gene mutation and the overexpression of P53 geneprotein not only exist in the invasive stage but also played some role in the early stage of the esophageal and cardiac carcinoma.

关 键 词：食管癌 贲门癌 P53蛋白 过度表达 

分 类 号：R735.102[医药卫生—肿瘤]