薄膜—均质法制备杨梅苷脂质体研究  

Study on preparation of the myricitrin liposome by membrane-homogeneous method

作　　者：郭瑞雪[1] 陈健[1] 谢彦瑰[1] 

机构地区：[1]华南理工大学轻工与食品学院,广东广州510640

出　　处：《粮食与油脂》2010年第1期44-47,共4页Cereals & Oils

基　　金：国家科技支撑计划(2006BAD27B04)资助

摘　　要：研究制备杨梅苷脂质体并优化工艺方法;以薄膜―均质法制备杨梅苷脂质体,并用高效液相色谱法测定药物含量和包封率,激光粒度仪测定平均粒径。最佳制备工艺为:杨梅苷∶卵磷脂=1∶6,磷酸盐缓冲溶液pH7.0,浓度0.005mol/L,均质压力100Mpa,均质三次,卵磷脂∶胆固醇=3∶1,有机相与水相比为4∶1;包封率、粒度和电位检测表明质量指标较好。To prepare the myricitrin liposome and prepared by Membrane-homogeneous method.The HPLC and the liposome entrapment efficiency was optimize the process. Myricitrin liposome was concentration of myricitrin was determined by calculated and the particle size was determined by particle size analyzer. The optimum formulations and the preparation technology were myricitrin： phospholipids= 1 ： 6, the buffer pH value was 7.0 and the buffer concentration was 0.005 mol/L, the homogeneous pressure was 100 Mpa, 3 times, the phospholipids： cholesterin was 3 ： 1, and oil-phase： water-phase was 4 ： 1. The quality indicators, the liposome entrapment efficiency, particle size, and potential were relatively good.

关 键 词：杨梅苷 脂质体 薄膜-均质法 

分 类 号：TS202.3[轻工技术与工程—食品科学]