精神分裂症与APOE基因的关联研究  

A study on the association between schizophrenia and APO E gene

作　　者：章连生[1] 陈文忠[1] 袁炳荣[1] 汪栋祥[1] 钱伊萍[1] 林嗣萃[1] 江三多[1] 罗星光[1] 江开达[1] 

机构地区：[1]上海市精神卫生中心

出　　处：《四川精神卫生》1998年第4期233-235,共3页Sichuan Mental Health

摘　　要：目的为了探讨汉族人ＡＰＯＥ基因与精神分裂症病因之间的关系。方法随机抽取２０７例精神分裂症患者作研究，以１６０例正常人作对照。用聚合酶链式反应（ＰＣＲ）扩增技术及限制性片段长度多态性（ＲＦＬＰｓ）技术测定所研究对象的ＡＰＯＥ基因型和等位基因。结果发现精神分裂症与ＡＰＯＥ基因的基因型及等位基因均无关联。Objective To investigate the relationship between schizophrenia and APO E gene.Methods The genotypes and alleles of APO E in 207 schizophrenic patients and 160 healthy controls were examined with PCR amplification and Restriction Fragment Length Polymorphisms(RFLPs) technique.The significance for genetic association of APO E gene was estimated by the χ 2 test .Result There is no association between schizophrenia and APO E gene.Conclusion Our finding suggests that APO E gene may not play a major role in the pathogenesis of schizophrenia in Han population.

关 键 词：精神分裂症 APO E基因 病因 

分 类 号：R749.302[医药卫生—神经病学与精神病学]