分子模拟技术在小分子免疫检测方法研究中的应用  

Application of Molecular Modeling Technique in development of Small Molecular Immunity Examination Methods

作　　者：王伟华[1] 雷红涛[1] 孙远明[1] 

机构地区：[1]华南农业大学食品学院/广东省食品质量安全重点实验室,广东广州510642

出　　处：《现代食品科技》2010年第1期102-108,共7页Modern Food Science and Technology

基　　金：国家"863"计划(2006AA10Z447);国家自然科学基金(20877029);粤港关键领域重点突破招标项目(2006A25005002)

摘　　要：量子力学法、分子力学法、蒙特卡洛法和分子动力学法是4种常用的分子模拟技术。本文重点综述了分子模拟技术在小分子免疫检测方法研究中的应用,分子模拟技术能够更好地研究抗原抗体反应中的分子间作用力,促进抗原抗体反应识别机制研究的深入进行,能够解释抗体的交叉反应率,从而能应用于提高抗体宽谱性提高的研究。In lifts article, several molecular modeling methods were systematically reviewed including quantum mechanics method, molecular mechanics method, Monte Carlo meflaod and molecular dynamics method. The application of molecular modeling technique in ltae study of the small rnoleeular immunity examination methods was explored. It was found that molecular modeling could enhance the intermoleeular action between antigen and antibody well, advanced the research of the recognition mechanism of immunoreaction was advanced, and improve broad specificity of antibody.

关 键 词：分子模拟 免疫检测方法 识别机制 

分 类 号：TS207[轻工技术与工程—食品科学]