MCM7和Ki-67在乳腺癌中的表达及其与新辅助化疗关系的研究  

Relationship between expression of MCM7 and Ki-67 and response to neoadjuvant chemotherapy in breast cancer

作　　者：戴文斌[1] 黄平[2] 任占平[1] 石喆[1] 张芫[1] 杨立[1] 

机构地区：[1]柳州市人民医院病理科,广西柳州545006 [2]柳州市人民医院乳腺外科,广西柳州545006

出　　处：《实用肿瘤杂志》2010年第1期20-23,共4页Journal of Practical Oncology

基　　金：广西自然科学基金资助项目(0991270)

摘　　要：目的探讨乳腺癌新辅助化疗前后MCM7和Ki-67蛋白的表达状况,分析其与化疗疗效的关系。方法采用免疫组化方法检测55例乳腺癌新辅助化疗前后标本中MCM7和Ki-67的表达。结果新辅助化疗有效率为76.4%。化疗前MCM7和Ki-67蛋白阳性表达均显著高于化疗后(P<0.01);化疗前MCM7蛋白阳性表达显著高于Ki-67(P<0.01)。化疗有效组(42例)MCM7蛋白阳性表达显著高于无效组(13例)(P<0.01),而Ki-67蛋白表达差异无统计学意义(P>0.05)。化疗前MCM7、Ki-67表达呈正相关(r=0.58,P<0.01)。结论ET方案新辅助化疗有较好的疗效,可能通过抑制MCM7、Ki-67蛋白的表达阻止乳腺癌细胞的增殖。MCM7蛋白高表达者化疗更敏感,MCM7可作为临床指导乳腺癌化疗并预测化疗敏感性的分子生物学指标之一。Objective To study the expressions of MCM7 and Ki-67 before and after neoadjuvant chemotherapy in breast cancer patients,and to analyze the relationship with response to neoadjuvant chemotherapy.Methods The expressions of MCM7 and Ki-67 before and after neoadjuvant chemotherapy were examined by immunohistochemistry in 55 cases of breast cancer.Results The overall response rate to neoadjuvant chemotherapy was 76.4%.The positive expressions of MCM7 and Ki-67 before neoadjuvant chemotherapy were significantly higher than those after neoadjuvant chemotherapy（P〈0.01）.The positive expression of MCM7 was significantly higher than that of Ki67 in breast cancer before neoadjuvant chemotherapy（P〈0.01）.The positive expression of MCM7 in the group of response to neoadjuvant chemotherapy was significantly higher than that of no response to neoadjuvant chemotherapy（P〈0.01）,but there was no statistical difference in the expression of Ki-67（P〉0.05）.Before neoadjuvant chemotherapy,the expression of MCM7 was positively correlated with the expression of Ki-67（r=0.58,P〈0.01）.Conclusions Neoadjuvant chemotherapy with ET regimen is effective,and it may inhibit the proliferatation of breast cancer cells by downregulation of the expression of MCM7 and Ki-67.Patients with high expression of MCM7 were more likely to respond to chemotherapy.The expression of MCM7 as biological marker could be a guide for chemotherapy and prediction for its response to chemotherapy in breast cancer.

关 键 词：乳腺肿瘤 化学疗法 辅助 MCM7 KI-67 免疫组织化学 预后 

分 类 号：R737.9[医药卫生—肿瘤]