细菌内毒素法用于甲硝唑注射液的热原检查  

Examination on pyrogen of metronidazole injection by bacteria endotoxin method

作　　者：杜凤菊[1] 兴连菊[1] 

机构地区：[1]哈尔滨242医院,哈尔滨市平房区卫处街3号150066

出　　处：《航空航天医药》1998年第4期196-197,共2页Aerospace Medicine

摘　　要：目的：探讨应用细菌内毒素法测甲硝唑注射液的热原。方法：应用鲎试剂与细菌内毒素产生凝聚反应的机理以判断供试品中细菌内毒素的限量是否符合规定的一种方法。结果：兔法与细菌内毒素法实验比较无显著差异。结论：细菌内毒素法测定热原具有快速、灵敏度高、省时、省力等优点。Objective: To determine the pyrogtn of metronidazole injection. METH0DS: Apply the coacervation mechanism of limulus reagent and bacteria endotoxin to judge it endotoxic limes in specimen was corresponding to the prescript. RESULTS =Compared with lapinization it showed no difference. CONCLUSION:Bacteria endotoxin method was simple quick and high sensitivity.

关 键 词：细菌内毒素 甲硝唑 热原 鲎试剂 

分 类 号：R978.61[医药卫生—药品] R927.12[医药卫生—药学]